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Printable Handouts
Navigable Slide Index
- Introduction
- Aging (senescence) results from natural selection
- But, don’t women stop reproducing in mid-life?
- Is our longevity a recent novelty?
- Global maximum life expectancy, 150 years ago
- Age distribution of females in Sweden in 1841
- Women living past fertility
- GC Williams 1957
- WD Hamilton 1966 (1)
- WD Hamilton 1966 (2)
- Alternative hypotheses
- Other lines of evidence
- Hadza project
- Compare humans & chimpanzees
- Grandmother hypothesis (1)
- Grandmother hypothesis (2)
- Grandmother hypothesis (3)
- Peter Kim’s agent-based model
- How do we do it?
- Investigating aging physiology
- Estrogen production
- Adrenal androgens
- Adrenal androgens and aging (1)
- Adrenal androgens and aging (2)
- Telomere shortening
- Female fertility by 45
- Age-specific fertility rates (1)
- Age-specific fertility rates (2)
- Women usually outlive their fertility (1)
- Women usually outlive their fertility (2)
- Women usually outlive their fertility (3)
- Low fertility females leave risk pool earlier
- Differences in mortality and ASFR shapes
- Higher human survival with ovarian aging conserved
- Not so chimpanzees
- Higher human survival: heterogeneity in fertility
- Utah women born in 19th century (1)
- Utah women born in 19th century (2)
- Global life expectancy <50 years 150 years ago
- US 2010 & Hazda
- Aging & our evolved life history
Topics Covered
- Aging (senescence) our evolved life history
- Global maximum life expectancy
- Postmenopausal survival characterizes all human populations
- Longevity affects age at maturity across our primate order
- Comparing humans and chimpanzees
- Grandmother effects and the evolution of human life history
- What physiological mechanisms have slowed human aging?
- Age-specific fertility rates in humans & chimpanzees
- Overall mortality effects on age-specific variation
Links
Series:
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Therapeutic Areas:
Talk Citation
Hawkes, K. (2017, April 30). Human aging and menopause [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 21, 2024, from https://doi.org/10.69645/BXVW1014.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Kristen Hawkes has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
A selection of talks on Genetics & Epigenetics
Transcript
Please wait while the transcript is being prepared...
0:00
I'm Kristen Hawkes.
I'm an evolutionary anthropologist
at the University of Utah.
And my topic is "Human Aging
and Menopause".
I'm an evolutionary anthropologist
and so that means
that I think in terms of natural selection
as the key to explaining
why things vary in the living world.
And if you think about natural selection,
aging initially looks like quite a riddle.
But, of course,
we're not the only ones that age.
Aging is a thing about living organisms.
And so evolutionary biology
has given us some crucial tools.
Hence, thinking about
how we live in a finite world,
all organisms do, it means that
there are always tradeoffs.
And because there are tradeoffs,
aging senescence is a necessary result
from natural selection.
0:53
More is spent on maintenance and repair means
less can be spent on current reproduction.
And so the tradeoff between those two things
provides this wonderful leverage
for explaining variation.
This figure shows that tradeoff between
what's put into somatic maintenance
and repair on the one hand,
and what's put into current reproduction.
And if those parallel lines
represented lines of equal lifetime fitness,
the expectation is that selection
would adjust that tradeoff to hit the line
of highest lifetime fitness.
And it turns out to be
a very powerful toolkit
for explaining some of the variation
in rates of aging across the living world.
How much goes into maintenance
and repair depends on,
first of all, what the chances are
of surviving to older ages.
If the chances are very low,
if mortality is very high,
then that kind of investment won't payoff.
And so when mortality is low, it does.
And it also matters
what the reproductive payoff is
if you do survived to those ages.