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Printable Handouts
Navigable Slide Index
- Introduction
- Disclosure
- Talk outline
- Current treatment for endometriosis
- Pathophysiology
- Proliferation
- Anti-proliferation by progesterone
- New progestin and SPRM
- Anti-proliferation
- Anti-proliferation mechanism (1)
- Anti-proliferation mechanism (2)
- Anti-recurrence
- Summary (efficacy)
- Summary (safety)
- Immunology
- Anti-immune escape by immunomodulator
- Immunosuppression
- Immune response in early endometriosis
- Myeloid-derived suppressor cells (MDSCs)
- T cell suppression
- MDSC depletion
- Molecular targets
- Potential immuno-modulator
- Adhesion
- Anti-adhesion by herbal medicines
- Common TCM formulas
- Anti-endometriosis (herbal medicine)
- Anti-endometriosis mechanism
- Common individual herbs
- Single herb & dose dependent effects
- Angiogenesis
- Anti-angiogenesis by green tea
- Camellia sinensis
- Tea polyphenols (catechins)
- Biological properties
- Anti-endometriosis (EGCG)
- Anti-angiogenesis
- Anti-angiogenesis mechanism
- Prodrug of EGCG (pro-EGCG)
- Efficacy of pro-EGCG
- Molecular interactions
- RCT of green tea for endometriosis
- Summary
- Thanks & contact info
Topics Covered
- Limitation of current treatment of endometriosis
- Pathophysiology of endometriosis
- Anti-proliferation of endometriosis by new progesterone
- Anti-immune escape of endometriosis by immunomodulator targeting MDSCs
- Anti-adhesion of endometriosis by herbal medicines and active components
- Anti-angiogenesis of endometriosis by green tea and derivatives
- Pharmacokinetics of biologics
Links
Categories:
Therapeutic Areas:
Talk Citation
Wang, C.C.(. (2019, April 30). Research & development of new pharmaceuticals for treatment of endometriosis [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 11, 2024, from https://doi.org/10.69645/HPSA5071.Export Citation (RIS)
Publication History
Financial Disclosures
- Professor Wang has a patented USPTO 9713603, licenced to Aptorum Therapeutics Ltd., and grants GRF 475012, HMRF 03141386, and ITF ITS/209/12
Research & development of new pharmaceuticals for treatment of endometriosis
Published on April 30, 2019
49 min
A selection of talks on Reproduction & Development
Transcript
Please wait while the transcript is being prepared...
0:00
Hi everybody. Thank you for your interest to my talk.
My name is Wang Chi Chiu Ronald,
or you can call me Ronald.
I am the Professor and Division Head of the Department
of O&G in The Chinese University of Hong Kong.
Here's where we all know,
I'm happy to have a talk in Henry Stewart Talks.
The topic of my talk is "R&D of New Pharmaceuticals for Treatment of Endometriosis".
From the topic, you can see that I'm going to cover the treatment
of endometriosis and R&D of the new pharmaceuticals.
So, I hope you like it and find it very useful.
0:41
So, first of all,
I would like to disclose my collaborations,
funding, patents, and licenses.
So, you can see that I have several collaborations with Hiu Xu in
Hong Kong, McGill University and University of Oxford and also Havard University,
Columbia University, and South Carolina.
The funding mainly is from Hong Kong.
One of them is RGC GRF,
the second is ITF Tier 3 ITS and the last one is the HMRF.
So, some of the contacts have a patents already.
So, you can identify the ID of the patents here.
One of the technology has been licensing through the pharmaceutical company.
1:29
So, basically, the talk today will cover three areas.
First of all, I will give you some background information,
such as why we need the pharmaceuticals and
how we are going to design the new pharmaceuticals.
So we're going to talk about some physiology.
In the second part, we are going to introduce four main new pharmaceuticals that includes
progesterone, immunodulators, herbal medicine,
and lastly I'm going to give you a summary.
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