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1. Introduction
2. Calcium as a signaling molecule
3. Ca2+: the 2nd messenger of electrical activity
4. Voltage-gated Ca2+ channel functions
5. Structural features for feedback inhibition
6. Inactivation of L-type channels: feedback inhibition
7. Timothy syndrome
8. Ca2+ channel inactivation: the Ca2+ sensor in action
9. New modes of CaM interaction and action
10. Calcium and sodium channels, NMDA receptors
11. Components for Ca2+ channel modulation
12. The Ca2+-binding protein KChIP
13. Pleiotropic KChIP2-/- effects
14. Ca2+ current reduced in KChIP2-/- myocytes
15. KChIP2 increases Ca2+ current directly
16. Ca2+ independent effects
17. Site of action is alpha-1c N terminus
18. Model: relief of inhibition at N terminus
19. CaM as a constitutive subunit
20. Calmodulin as an ion channel subunit
21. Trafficking in hippocampal neurons
22. CaM-regulated trafficking is activity-dependent
23. New model for calmodulin interaction and CDI
24. Ca2+-dependent inactivation of NMDA-Rs
25. New model for CaM interaction with NMDA-Rs
26. CaM interaction is Ca2+-dependent
27. CaM "dimerizes" NR1 CTs
28. Ca2+/CaM drives a reversible dimerization
29. New model for NMDA-R CDI
30. Decoupling NR1 CTs abolishes CDI
31. Ca2+ regulation of sodium channels
32. Ca2+ regulation of sodium channel function
33. Site(s) of Ca2+ regulation: EF hand
34. Site(s) of Ca2+ regulation: IQ motif
35. Solution structure of the NaV1.2/1.5 C terminus
36. Channels regulated by calcium
37. Channels regulated by calmodulin

Topics Covered

• Ion channel function
• Regulation by calcium
• Role of calmodulin as the calcium sensor
• Physiological consequences

Links

Series:

• Ion Channels

Categories:

• Biochemistry
• Cell Biology

Talk Citation

Publication History

• Published on February 28, 2011

Financial Disclosures

• Prof. Geoffrey S. Pitt has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.