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1. Introduction
2. Ion channel phosphorylation in physiology
3. Lecture structure
4. Overview of ion channel phosphorylation
5. Time domains and modes of ion channel regulation
6. Reversible protein phosphorylation
7. Human kinome and phosphome
8. Serine/threonine kinases and phosphatases
9. Channel phosphorylation and short-term memory
10. Ca-activated K channel phosphorylation by PKA
11. Multistate networks of protein phosphorylation
12. Ion channel regulation via phosphorylation
13. BK channels as a model for phosphorylation
14. PKA phosphorylation sites in BK channel
15. Analysing ion channel regulation in real time
16. Monitoring single ion channels in real time
17. ZERO variant BK channels are activated by PKA
18. STREX variant BK channels are inhibited by PKA
19. S3STREX and S899 are phosphorylated by PKA
20. Controlling divergent regulation by PKA (1)
21. Controlling divergent regulation by PKA (2)
22. Multimeric channels as phosphorylation abacus
23. Phosphoproteomic complexity in rat BK channels
24. Regulation by (de)phosphorylation in Kv2.1
25. How phosphorylation controls channel activity
26. Channel regulation by dephosphorylation
27. PP2A inhibits rat brain BK channels
28. Regulation of BK channels via dephosphorylation
29. Regulation of BK channels by protein phosphatase
30. Conditional regulation by phosphorylation
31. PKC switches BK channel regulation
32. PKC conditionally regulates BK channels
33. Palmitoylation regulation of STREX BK channels
34. Channels and phosphorylation signalling complexes
35. Channel assembly with kinases/phosphatases
36. Direct interaction of PKAc at PKA consensus site
37. Indirect interaction via adapter proteins (1)
38. Indirect interaction via adapter proteins (2)
39. LZ1 common motif for splice variant regulation
40. Macromolecular assembly of PKA with BK channel
41. Regulation via phosphor. of signalling complex
42. Yotiao phosphorylation required for PKA activation
43. Cortactin phosphorylation controls BK regulation
44. Control of channel trafficking and expression
45. Kv2.1 dephosphorylation regulates localisation
46. BK phosphorylation controls alternative splicing
47. Phosphorylopathies
48. New phosphorylation site in hERG1 polymorphism
49. New CamKII site in CaV1.2 mutation
50. KCNQ1 mutation disrupts signalling complex
51. Some future challenges
52. Acknowledgements

Topics Covered

• Overview of ion channel phosphorylation
• Regulation via phosphorylation of ion channel pore forming subunits
• Channel regulation by dephosphorylation
• Conditional regulation: posttranscriptional and posttranslational crosstalk
• Channels and phosphorylation signalling complexes
• Ion channel regulation via phosphorylation of signalling complexes
• Control of channel trafficking and expression by phosphorylation
• Diseases due to aberrant ion channel phosphorylation
• Future challenges

Links

Series:

• Ion Channels

Categories:

• Biochemistry

Talk Citation

Publication History

• Published on February 28, 2011

Financial Disclosures

• Prof. Mike Shipston has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.