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- Diversity of Ion Channels
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1. The diversity and evolution of ion channels
- Dr. Tim Jegla
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2. Alternative splicing and calcium ion channel diversity
- Prof. Diane Lipscombe
- Ion Channel Structure and Function
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3. Functional modules in ion channels
- Dr. Richard Horn
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4. Voltage-dependent gating of ion channels
- Dr. Keith S. Elmslie
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5. M-current and its role in neuronal physiology
- Prof. David A. Brown
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6. KATP channels and insulin secretion
- Prof. Frances Mary Ashcroft
- Ion Channel Modulation
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7. Regulation of neuron accuracy by modulation of potassium channels
- Prof. Leonard Kaczmarek
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8. Ion channel regulation by phosphorylation
- Prof. Mike Shipston
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10. Calcium regulation of ion channels
- Prof. Geoffrey S. Pitt
- Ion Channels and Neuronal Plasticity
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11. Modulation of intrinsic neuronal excitability 1
- Prof. Nelson Spruston
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12. Modulation of intrinsic neuronal excitability 2
- Prof. Nelson Spruston
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13. Glutamate receptor modulation and long-term synaptic plasticity
- Prof. Graham Collingridge
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14. Cellular mechanisms of neuromodulation in a small neural network
- Prof. Ronald M. Harris-Warrick
- Ion Channels and Disease
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15. Kv10.1 potassium channels in cancer
- Prof. Luis Pardo
- Archived Lectures *These may not cover the latest advances in the field
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17. KV10.1 potassium channels in cancer
- Prof. Luis Pardo
Printable Handouts
Navigable Slide Index
- Introduction
- The first cell
- Investigating function
- Gating versus permeation
- Tools for investigating function: electrophysiology
- Tools for investigating function: blockers
- Blocker
- State dependent access
- Foot in the door
- An example - fast block
- Tools for investigating function: mutagenesis
- Point mutations
- Channel topology
- The pore region in sodium channels
- TTX attraction to neutral aromatic residue
- QM/MM model
- Chimeras
- Examples of chimeras: KcsA and Shaker
- Examples of chimeras: sodium and potassium (1)
- Examples of chimeras: sodium and potassium (2)
- Tools for investigating function: SCAM
- Substituted cysteine accessibility method
- Methanethiosulfonate reagents
- Substituted cysteine accessibility method
- Designing a voltage-gated channel
- S4 segment movement
- Tools for investigating: fluorescence probes
- FluoProbes
- Tools for investigating function: simulations
- Conclusions
Topics Covered
- Methods used to study the biophysical properties of ion-channel function
- Relationship between ion channel structure and function
Talk Citation
Horn, R. (2011, February 28). Functional modules in ion channels [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 26, 2024, from https://hstalks.com/bs/1950/.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Richard Horn has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.