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Printable Handouts
Navigable Slide Index
- Introduction
- Bioelectrical signals
- What is bioelectricity?
- Defining bioelectricity
- Big questions about bioelectricity
- Sources of bioelectrical signals
- Physiological side effect or instructive signal?
- Membrane voltage and cell plasticity
- History of the field
- Take home messages
- Outline
- Applying exogenous electric fields in vitro
- Microelectrode impalement
- Detection of extracellular ion flux
- Investigating signals in pattern formation
- Inverse pharmacological screen
- Transmembrane voltage gradient characterization
- Loss- and gain-of-function analyses
- Synthesizing data into a predictive model
- Control of cell behavior by electric fields
- Mammalian stem cell differentiation
- Cell orientation and outgrowth
- Transepithelial potentials, electric fields, cancer
- Mechanisms of electric field sensing by cells
- Tissue-level electric fields and their function
- Electric fields and tissue repair
- Bioelectric signals in 3D morphogenesis
- Bioelectric signals in morphogenetic events (1)
- Bioelectric signals in morphogenetic events (2)
- Transmembrane potential in tail regeneration (1)
- Transmembrane potential in tail regeneration (2)
- V-ATPase function in tail regeneration
- V-ATPase activity is required for tail regeneration
- V-ATPase needed for endogenous regeneration
- Using voltage- and pH-sensitive dyes
- Induction of the V-ATPase following injury
- Electrogenic targets in mitosis upregulation
- Axon patterning requires specific ion fluxes
- Gene expression requires specific ion flows
- A pathway for tail regeneration
- Can ion flux induce regeneration?
- Summary (1)
- Voltage gradients control large-scale axial polarity
- Transmembrane potential and cell behavior
- The Goldman equation
- Missexpressing specific ion transporter mRNAs
- Melanocyte behavior & transmembrane potential
- Taking advantage of endogenous ion transport
- Controlling transmembrane potential
- Controlling proliferation rates using K channels
- Properties of cells and transmembrane potential
- Effects of transmembrane potential changes
- Modulation of transmembrane potential
- Molecular mechanisms
- Cell-autonomous mechanisms
- Non-cell-autonomous mechanisms:
- Bioelectrical signals and canonical pathways
- Properties of bioelectrical signaling
- Bioelectric gradients and gene expression
- Bioelectrical signals are fundamental
- Bioelectrical signals exert long-range effects
- Information carried by bioelectric signals
- Ion channel genes may be irrelevant
- Bioelectrical mechanisms, DNA, mRNA & protein
- Control of ion flux is often a "master regulator"
- Future prospects
- Cell types live in a biophysical state space
- Applications in cancer, stem cells & regeneration
- Light-gated ion transporters
- Summary (2)
- Acknowledgements
Topics Covered
- Defining bioelectricity
- Sources of bioelectrical signals
- Big questions about bioelectricity
- Membrane voltage and cell plasticity
- History of the field of bioelectricity
- Applying exogenous electric fields in vitro
- Microelectrode impalement
- Detection of extracellular ion flux
- Investigating signals in pattern formation
- Inverse pharmacological screen
- Transmembrane voltage gradient characterization
- Loss- and gain-of-function analyses
- Synthesizing data into a predictive model
- Control of cell behavior by electric fields
- Mammalian stem cell differentiation
- Cell orientation and outgrowth
- Transepithelial potentials, electric fields, cancer
- Mechanisms of electric field sensing by cells
- Bioelectric signals in 3D morphogenesis
- A pathway for tail regeneration
- Transmembrane potential in tail regeneration
- V-ATPase function in tail regeneration
- Using voltage- and pH-sensitive dyes
- Induction of the V-ATPase following injury
- Electrogenic targets in mitosis upregulation
- Axon patterning requires specific ion fluxes
- Gene expression requires specific ion flows
- Ion flux and induction of regeneration
- Voltage gradients control large-scale axial polarity
- Transmembrane potential and cell behavior
- The Goldman equation
- Missexpressing specific ion transporter mRNAs
- Melanocyte behavior & transmembrane potential
- Taking advantage of endogenous ion transport
- Controlling transmembrane potential
- Modulation of transmembrane potential
- Controlling proliferation rates using K channels
- Cell-autonomous mechanisms
- Non-cell-autonomous mechanisms
- Bioelectrical signals and canonical pathways
- Bioelectric gradients and gene expression
- Information carried by bioelectric signals
- Bioelectrical mechanisms, DNA, mRNA & protein
- Control of ion flux as a "master regulator"
- Applications in cancer, stem cells & regeneration
- Light-gated ion transporters
Talk Citation
Levin, M. (2011, February 23). Endogenous bioelectrical signals in development, regeneration, and neoplasm [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 10, 2024, from https://doi.org/10.69645/CKYR4064.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Michael Levin has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Endogenous bioelectrical signals in development, regeneration, and neoplasm
Published on February 23, 2011
55 min
A selection of talks on Oncology
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