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1. Introduction
2. Professor Anthony Axon
3. Incidences and mortality of cancer types
4. Scanning EM of Helicobacter pylori
5. Aims of this presentation
6. Transmission EM of Helicobacter pylori
7. Acute infection with H. pylori
8. Biopsies of acute gastric inflammation
9. Chronic gastritis with "activity" in the antrum
10. Helicobacter gastritis before and after treatment
11. H. pylori gastric mucosa interactions
12. Atrophy and intestinal metaplasia after infection
13. H. pylori, gastric atrophy and IM over time
14. Natural history of Hp Gastritis
15. Hp as an essential risk factor for gastric cancer
16. Association between Hp and gastric cancer
17. Problems with IgG ELISA serology
18. Gastric cancer and Hp - corrected for CagA
19. Helicobacter gastritis and gastric acidity (1)
20. Type of gastritis and cancer risk
21. Corpus atrophy in gastric cancer
22. Conclusive flow chart
23. H. pylori infection in animal models
24. H. pylori and gastric cancer - summary
25. Mechanisms involved in gastric carcinogenesis
26. Does Hp itself directly cause gastric cancer?
27. The Correa hypothesis
28. Epithelial cell proliferation and Hp eradication
29. Gastric ascorbic acid conc. and Hp eradication
30. Reactive oxygen species in H, pylori gastritis
31. Effect of treatment
32. Stem cells
33. Bone marrow derived cells
34. Bone marrow derived cells and gastric cancer
35. New model for gastric cancer development
36. Appreciate why gastric cancer incidence varies
37. World map of gastric cancer mortality
38. Why does gastric cancer vary in incidence?
39. Hp and the socio-economically disadvantaged
40. Japanese versus British gastritis
41. Comparison of gastritis in matched populations
42. IM and atrophy in matched populations
43. Differing gastritis patterns in Japan and England
44. Difference in diet
45. Dietary factors influence on gastric cancer
46. Effects of the CagA pathogenicity island
47. Non-cardia cancer and Hp genotypes
48. Genetics and gastric cancer
49. Proinflammatory cytokine gene polymorphisms
50. Hp and host genetics and carcinogenic effects
51. Helicobacter gastritis and gastric acidity (2)
52. Inflammation in the corpus and acid secretion
53. Corpus atrophy after acid suppression treatment
54. Increasing acid secretion in Japan
55. Acid secretion is related to lean body mass
56. Increasing height of men in Europe 1960-1990
57. Immune experience
58. Summary

Topics Covered

• Helicobacter pylori (Hp) and gastric cancer
• Natural history of Hp gastritis
• Hp as an essential risk factor
• Mechanisms of carcinogenesis
• Why the variation in cancer incidence?

Links

Series:

• Gastroenterology and Hepatology

Categories:

• Cancer
• Clinical Practice

Therapeutic Areas:

• Gastroenterology & Nephrology
• Oncology

Talk Citation

Publication History

• Published on May 9, 2011

Financial Disclosures

• Prof. Anthony Axon has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.