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1. Introduction
2. Ubiquitination vs. phosphorylation (1)
3. Ubiquitination vs. phosphorylation (2)
4. Ubiquitination vs. phosphorylation (3)
5. Ubiquitin-binding domains
6. Ubiquitination vs. phosphorylation (4)
7. Ubiquitin signaling in the NF-kappaB pathway
8. NF-kappaB signaling pathway
9. The biochemical pathway of IkB ubiquitination (1)
10. The biochemical pathway of IkB ubiquitination (2)
11. The IL-1R/toll-like receptor pathway
12. TRAF-6, Nemo-dependent IKK activation in vitro
13. Activation of IKK by TRAF6 requires two factors
14. TRAF6-regulated IKK activator-2
15. Ubc13 is required for IKK activation by IL-1beta
16. Catalytic activity of Ubc13
17. TRIKA1 = Ubc13/Uev1A
18. Domain organization of TRAFs
19. TRAF6 is a ubiquitin ligase
20. Polyubiquitin chains
21. K63-linked polyUb chains mediate IKK activation
22. Human ubiquitin genes
23. An inducible ubiquitin "knock-in" system
24. K63 is required for IKK activation by IL-1beta
25. TRIKA2 = TAK1/TAB1/TAB2
26. Ubiquitin activation of stress kinases
27. The proposed model
28. The CYLD and NEMO pathologies
29. Innate and adaptive immunity
30. Acknowledgement

Topics Covered

• Ubiquitination is a reversible covalent modification, akin to phosphorylation
• Ubiquitination regulates protein kinase activity through proteasome-independent mechanisms
• K63-linked polyubiquitination activates TAK1 and IKK in the NF-kappaB pathway
• Deubiquitination enzymes inhibit protein kinases in the NF-kappaB pathway
• Protein kinase regulation by ubiquitin is important in innate and adaptive immunity

Links

Series:

• Protein Phosphorylation

Categories:

• Biochemistry
• Cell Biology

Talk Citation

Chen, Z.'. (2010, November 30). The interplay between protein phosphorylation and ubiquitylation in the NF-κB pathway [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 19, 2025, from https://doi.org/10.69645/PGQM8626.
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Publication History

• Published on November 30, 2010

Financial Disclosures

• Prof. Zhijian 'James' Chen has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.