• The Discovery of Protein Phosphorylation
• 45 min
  1. Phosphorylase and the origin of reversible protein phosphorylation

  • Prof. Edmond Fischer
• 21 min
  2. Three decades of protein phosphorylation and cancer: the identification and characterization of the src gene product

  • Prof. Raymond Erikson
• Protein Kinase Cascades
• 32 min
  3. Role of the PI 3-kinase signaling pathway in cell regulation and human disease

  • Prof. Lew Cantley
• The Modulation of Protein Function by Phosphorylation
• 33 min
  4. Two is the key to 14-3-3: dimeric mechanical signaling devices

  • Prof. Carol MacKintosh
• Protein Phosphatases
• 38 min
  5. Structure and mechanisms of protein phosphatases

  • Prof. David Barford
• 45 min
  6. Protein tyrosine phosphatases

  • Prof. Jack Dixon
• 49 min
  7. The regulation of MAP kinase signalling by dual-specificity protein phosphatases

  • Prof. Steve M. Keyse
• 22 min
  8. Protein phosphatase inhibitors: a distillation of cell signaling research and water toxicology

  • Prof. Carol MacKintosh
• The Structures of Protein Kinases
• 45 min
  9. Protein kinase structure, function and regulation

  • Prof. Susan Taylor
• 42 min
  10. The structural basis for the modulation of protein function by protein phosphorylation

  • Prof. Dame Louise N. Johnson
• Biological Systems that are Regulated by Reversible Phosphorylation
• 50 min
  11. Protein phosphorylation and the control of protein synthesis

  • Prof. Christopher Proud
• 62 min
  12. The role of phosphorylation in mediating cellular responses to DNA damage: the ATM-mediated DNA damage response

  • Prof. Yosef Shiloh
• 40 min
  13. Roles of AMPK in energy homeostasis and nutrient sensing

  • Prof. Grahame Hardie
• 56 min
  14. Serine kinases and T lymphocyte biology

  • Prof. Doreen Cantrell
• 30 min
  15. The interplay between protein phosphorylation and ubiquitylation in the NF-κB pathway

  • Prof. Zhijian 'James' Chen
• 58 min
  16. SMAD phosphorylation and the TGF-beta pathway

  • Prof. Joan Massagué
• Protein Kinases and Human Disease
• 58 min
  17. Function and regulation of the PDK1 kinase

  • Prof. Dario Alessi
• 63 min
  18. LKB1 pathway and its role in cancer

  • Prof. Dario Alessi
• 51 min
  19. WNK1 pathway and its role in regulating hypertension

  • Prof. Dario Alessi
• 33 min
  20. The hyperphosphorylation of tau and Alzheimer's disease

  • Prof. Michel Goedert
• Protein Kinases as Targets for the Development of Anti-Cancer Drugs
• 68 min
  21. PI3K/AKT signaling in cancer

  • Prof. Neal Rosen
• 37 min
  22. RAS and RAF signaling in melanoma: biology and therapies

  • Prof. Richard Marais
• 38 min
  23. The mTOR kinase as a target for anti-cancer drugs

  • Prof. David Sabatini
• Archived Lectures *These may not cover the latest advances in the field
• 51 min
  24. Modular protein-protein interactions provide a general mechanism to organize dynamic cellular systems

  • Prof. Tony Pawson
• 38 min
  25. AMP-activated protein kinase: regulating cellular and whole body energy balance

  • Prof. Grahame Hardie

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Talk outline
3. Why a signalling pathway activated by AMP?
4. Phosphotransfer relays: creatine and AMP
5. Regulation of AMPK by AMP and ATP
6. Function of AMPK orthologues in lower eukaryotes
7. AMPK as a drug target in type 2 diabetes
8. Regulation of metabolism by AMPK activation
9. Regulation of AMPK by drugs, cytokines and more
10. Anti-diabetic drugs: phenformin and metformin
11. Phytochemicals from foods, beverages and more
12. Identification of upstream kinases
13. AMPK regulation - upstream kinases
14. The budding yeast kinome (1)
15. Activation of AMPK by yeast kinases
16. The budding yeast kinome (2)
17. The human kinome
18. LKB1 - a tumour suppressor
19. More upstream kinase - CaMKKs
20. Upstream kinases acting on AMPK
21. Identification of AMP-binding sites
22. Domain structure of AMPK
23. Mutations in gamma-2 CBS cause heart disease
24. Gamma-2 mutations reduce AMP and ATP binding
25. Mutated residues are involved in AMP binding (1)
26. Mutated residues are involved in AMP binding (2)
27. AMPK as a drug target in cancer
28. AMPK activators: potential anti-cancer drugs
29. AMPK activators protect PTEN+/- LKB1fl/fl mice
30. AMPK activation is reduced in breast tumours
31. AMP-activated protein kinase - conclusions
32. Acknowledgements

Topics Covered

• AMPK-activated protein kinase
• Role as a cellular energy sensor
• Role in lower eukaryotes
• Metabolic pathways targeted by AMPK
• Cytokines, drugs (including metformin) and xenobiotics that target AMPK
• Identification of upstream kinases
• Regulation by AMP, ATP and calcium ions
• Potential of AMPK as a drug target in cancer

Links

Series:

• Protein Phosphorylation

Categories:

• Biochemistry
• Cell Biology
• Metabolism & Nutrition

Talk Citation

Publication History

• Published on November 30, 2010
• Archived on November 28, 2021

Financial Disclosures

• Prof. Grahame Hardie has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.