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Navigable Slide Index

1. Introduction
2. Talk outline
3. Why a signalling pathway activated by AMP?
4. Phosphotransfer relays: creatine and AMP
5. Regulation of AMPK by AMP and ATP
6. Function of AMPK orthologues in lower eukaryotes
7. AMPK as a drug target in type 2 diabetes
8. Regulation of metabolism by AMPK activation
9. Regulation of AMPK by drugs, cytokines and more
10. Anti-diabetic drugs: phenformin and metformin
11. Phytochemicals from foods, beverages and more
12. Identification of upstream kinases
13. AMPK regulation - upstream kinases
14. The budding yeast kinome (1)
15. Activation of AMPK by yeast kinases
16. The budding yeast kinome (2)
17. The human kinome
18. LKB1 - a tumour suppressor
19. More upstream kinase - CaMKKs
20. Upstream kinases acting on AMPK
21. Identification of AMP-binding sites
22. Domain structure of AMPK
23. Mutations in gamma-2 CBS cause heart disease
24. Gamma-2 mutations reduce AMP and ATP binding
25. Mutated residues are involved in AMP binding (1)
26. Mutated residues are involved in AMP binding (2)
27. AMPK as a drug target in cancer
28. AMPK activators: potential anti-cancer drugs
29. AMPK activators protect PTEN+/- LKB1fl/fl mice
30. AMPK activation is reduced in breast tumours
31. AMP-activated protein kinase - conclusions
32. Acknowledgements

Topics Covered

• AMPK-activated protein kinase
• Role as a cellular energy sensor
• Role in lower eukaryotes
• Metabolic pathways targeted by AMPK
• Cytokines, drugs (including metformin) and xenobiotics that target AMPK
• Identification of upstream kinases
• Regulation by AMP, ATP and calcium ions
• Potential of AMPK as a drug target in cancer

Links

Series:

• Protein Phosphorylation

Categories:

• Biochemistry
• Cell Biology
• Metabolism & Nutrition

Talk Citation

Hardie, G. (2010, November 30). AMP-activated protein kinase: regulating cellular and whole body energy balance [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 22, 2024, from https://doi.org/10.69645/URHA6472.
Export Citation (RIS)

Publication History

• Published on November 30, 2010
• Archived on November 28, 2021

Financial Disclosures

• Prof. Grahame Hardie has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.