• The Discovery of Protein Phosphorylation
• 45 min
  1. Phosphorylase and the origin of reversible protein phosphorylation

  • Prof. Edmond Fischer
• 21 min
  2. Three decades of protein phosphorylation and cancer: the identification and characterization of the src gene product

  • Prof. Raymond Erikson
• Protein Kinase Cascades
• 32 min
  3. Role of the PI 3-kinase signaling pathway in cell regulation and human disease

  • Prof. Lew Cantley
• The Modulation of Protein Function by Phosphorylation
• 33 min
  4. Two is the key to 14-3-3: dimeric mechanical signaling devices

  • Prof. Carol MacKintosh
• Protein Phosphatases
• 38 min
  5. Structure and mechanisms of protein phosphatases

  • Prof. David Barford
• 45 min
  6. Protein tyrosine phosphatases

  • Prof. Jack Dixon
• 49 min
  7. The regulation of MAP kinase signalling by dual-specificity protein phosphatases

  • Prof. Steve M. Keyse
• 22 min
  8. Protein phosphatase inhibitors: a distillation of cell signaling research and water toxicology

  • Prof. Carol MacKintosh
• The Structures of Protein Kinases
• 45 min
  9. Protein kinase structure, function and regulation

  • Prof. Susan Taylor
• 42 min
  10. The structural basis for the modulation of protein function by protein phosphorylation

  • Prof. Dame Louise N. Johnson
• Biological Systems that are Regulated by Reversible Phosphorylation
• 50 min
  11. Protein phosphorylation and the control of protein synthesis

  • Prof. Christopher Proud
• 62 min
  12. The role of phosphorylation in mediating cellular responses to DNA damage: the ATM-mediated DNA damage response

  • Prof. Yosef Shiloh
• 40 min
  13. Roles of AMPK in energy homeostasis and nutrient sensing

  • Prof. Grahame Hardie
• 56 min
  14. Serine kinases and T lymphocyte biology

  • Prof. Doreen Cantrell
• 30 min
  15. The interplay between protein phosphorylation and ubiquitylation in the NF-κB pathway

  • Prof. Zhijian 'James' Chen
• 58 min
  16. SMAD phosphorylation and the TGF-beta pathway

  • Prof. Joan Massagué
• Protein Kinases and Human Disease
• 58 min
  17. Function and regulation of the PDK1 kinase

  • Prof. Dario Alessi
• 63 min
  18. LKB1 pathway and its role in cancer

  • Prof. Dario Alessi
• 51 min
  19. WNK1 pathway and its role in regulating hypertension

  • Prof. Dario Alessi
• 33 min
  20. The hyperphosphorylation of tau and Alzheimer's disease

  • Prof. Michel Goedert
• Protein Kinases as Targets for the Development of Anti-Cancer Drugs
• 68 min
  21. PI3K/AKT signaling in cancer

  • Prof. Neal Rosen
• 37 min
  22. RAS and RAF signaling in melanoma: biology and therapies

  • Prof. Richard Marais
• 38 min
  23. The mTOR kinase as a target for anti-cancer drugs

  • Prof. David Sabatini
• Archived Lectures *These may not cover the latest advances in the field
• 51 min
  24. Modular protein-protein interactions provide a general mechanism to organize dynamic cellular systems

  • Prof. Tony Pawson
• 38 min
  25. AMP-activated protein kinase: regulating cellular and whole body energy balance

  • Prof. Grahame Hardie

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Translation and control of gene expression (1)
3. Translation and control of gene expression (2)
4. Overview of mRNA translation and control
5. Eukaryotic protein synthesis (1)
6. Eukaryotic protein synthesis (2)
7. Global and specific control of mRNA translation
8. Phosphorylation of eIF2
9. Haemin regulation of mRNA translation
10. The HCR inhibitor and its substrate
11. Control of start site selection (1)
12. Control of start site selection (2)
13. Phosphorylated eIF2 inhibits eIF2B
14. Stress-activated eIF2 alpha kinases in mammals
15. eIF2 phosphorylation and translation
16. Role of PERK in endoplasmic reticulum stress
17. eIF2 alpha phosphorylation and stress responses
18. Role of PKR in anti-viral defences
19. PKR - viruses fight back
20. Direct regulation of eIF2B by phosphorylation
21. eIF2B epsilon is phosphorylated at multiple sites
22. mTOR and the control of translation
23. The TOR proteins
24. Two types of mTOR complex
25. mTORC1 signalling
26. mTORC1 and regulation of mRNA translation
27. S6 kinases and their substrates
28. Role of 4E-BPs: regulation of mRNA binding
29. Translation in eukaryotes: control of eIF4F (1)
30. Translation in eukaryotes: control of eIF4F (2)
31. eIF4F formation and general protein synthesis
32. mTORC1 signalling and disease
33. eIF4E is linked to cancer
34. mTORC1 is also linked to cancer
35. eIF4E is a target for 'oncogenic' pathways
36. eIF4E phosphorylation and translation (1)
37. eIF4E phosphorylation and translation (2)
38. eIF4E phosphorylation and translation (3)
39. Control of translation elongation
40. mTORC1 also controls translation elongation
41. Regulation of elongation
42. Elongation and protein synthesis
43. Insulin & dephosphorylation of eEF2 via mTORC1
44. Insulin inactivates eEF2 kinase via mTORC1
45. Control of eEF2 kinase by mTORC1
46. Regulatory inputs into eEF2 kinase: inhibition
47. Regulation of elongation by energy status
48. A role for AMPK
49. Regulatory inputs into eEF2 kinase: activation
50. Control of elongation
51. The control of protein synthesis

Topics Covered

• Protein synthesis
• Key step in gene expression that must be tightly controlled
• Signaling pathways regulate phosphorylation and activity of translation factor proteins
• Important in regulation of cell growth and division
• Defective control linked to human diseases such as cancer and cardiac hypertrophy

Links

Series:

• Protein Phosphorylation

Categories:

• Biochemistry
• Cell Biology

Talk Citation

Publication History

• Published on November 30, 2010

Financial Disclosures

• Prof. Christopher Proud has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.