• The Discovery of Protein Phosphorylation
• 45 min
  1. Phosphorylase and the origin of reversible protein phosphorylation

  • Prof. Edmond Fischer
• 21 min
  2. Three decades of protein phosphorylation and cancer: the identification and characterization of the src gene product

  • Prof. Raymond Erikson
• Protein Kinase Cascades
• 32 min
  3. Role of the PI 3-kinase signaling pathway in cell regulation and human disease

  • Prof. Lew Cantley
• The Modulation of Protein Function by Phosphorylation
• 33 min
  4. Two is the key to 14-3-3: dimeric mechanical signaling devices

  • Prof. Carol MacKintosh
• Protein Phosphatases
• 38 min
  5. Structure and mechanisms of protein phosphatases

  • Prof. David Barford
• 45 min
  6. Protein tyrosine phosphatases

  • Prof. Jack Dixon
• 49 min
  7. The regulation of MAP kinase signalling by dual-specificity protein phosphatases

  • Prof. Steve M. Keyse
• 22 min
  8. Protein phosphatase inhibitors: a distillation of cell signaling research and water toxicology

  • Prof. Carol MacKintosh
• The Structures of Protein Kinases
• 45 min
  9. Protein kinase structure, function and regulation

  • Prof. Susan Taylor
• 42 min
  10. The structural basis for the modulation of protein function by protein phosphorylation

  • Prof. Dame Louise N. Johnson
• Biological Systems that are Regulated by Reversible Phosphorylation
• 50 min
  11. Protein phosphorylation and the control of protein synthesis

  • Prof. Christopher Proud
• 62 min
  12. The role of phosphorylation in mediating cellular responses to DNA damage: the ATM-mediated DNA damage response

  • Prof. Yosef Shiloh
• 40 min
  13. Roles of AMPK in energy homeostasis and nutrient sensing

  • Prof. Grahame Hardie
• 56 min
  14. Serine kinases and T lymphocyte biology

  • Prof. Doreen Cantrell
• 30 min
  15. The interplay between protein phosphorylation and ubiquitylation in the NF-κB pathway

  • Prof. Zhijian 'James' Chen
• 58 min
  16. SMAD phosphorylation and the TGF-beta pathway

  • Prof. Joan Massagué
• Protein Kinases and Human Disease
• 58 min
  17. Function and regulation of the PDK1 kinase

  • Prof. Dario Alessi
• 63 min
  18. LKB1 pathway and its role in cancer

  • Prof. Dario Alessi
• 51 min
  19. WNK1 pathway and its role in regulating hypertension

  • Prof. Dario Alessi
• 33 min
  20. The hyperphosphorylation of tau and Alzheimer's disease

  • Prof. Michel Goedert
• Protein Kinases as Targets for the Development of Anti-Cancer Drugs
• 68 min
  21. PI3K/AKT signaling in cancer

  • Prof. Neal Rosen
• 37 min
  22. RAS and RAF signaling in melanoma: biology and therapies

  • Prof. Richard Marais
• 38 min
  23. The mTOR kinase as a target for anti-cancer drugs

  • Prof. David Sabatini
• Archived Lectures *These may not cover the latest advances in the field
• 51 min
  24. Modular protein-protein interactions provide a general mechanism to organize dynamic cellular systems

  • Prof. Tony Pawson
• 38 min
  25. AMP-activated protein kinase: regulating cellular and whole body energy balance

  • Prof. Grahame Hardie

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Different functions of phosphate attachment
3. Glycogen phosphorylase activation
4. Glycogen phosphorylase
5. GPb versus GPa (1)
6. GPb versus GPa (2)
7. Reaction catalysed by glycogen phosphorylase
8. Adrenaline to phosphorylase signalling pathway
9. Phosphorylase kinase
10. Phosphorylase kinase catalytic subunit
11. Cryo-EM studies on phosphorylase kinase
12. The phosphorylase kinase model
13. Protein kinases regulate the cell cycle
14. CDK2 as a model system (1)
15. CDK2 as a model system (2)
16. Phosphothreonine acts as an organizing centre
17. Proline specificity in CDK2
18. Checkpoint controls of CDK2 in the cell cycle
19. Active CDK2 with ATP and substrate
20. CDK2 in action
21. The retinoblastoma protein and gene expression
22. P27kip1 - a Cdk inhibitor and activator
23. Cyclin E and cancer
24. STAT
25. Consequences of protein phosphorylation
26. References

Topics Covered

• Physical-chemical basis for phosphorylation
• Discovery
• Glycogen phosphorylase
• Signaling from adrenaline to phosphorylase
• Phosphorylase kinase still a challenge
• Regulation of the cell cycle by phosphorylation
• Cyclin dependent protein kinase 2 activation and inhibition
• Rb the guardian of the genome
• Control by p27 and cyclin E
• Summary of the structural consequences of phosphorylation

Links

Series:

• Protein Phosphorylation

Categories:

• Biochemistry

Talk Citation

Johnson, L.N. (2010, November 30). The structural basis for the modulation of protein function by protein phosphorylation [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved January 15, 2025, from https://doi.org/10.69645/XRXJ4467.
Export Citation (RIS)

Publication History

• Published on November 30, 2010

Financial Disclosures

• Prof. Dame Louise N. Johnson has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.