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Navigable Slide Index

1. Introduction
2. Different functions of phosphate attachment
3. Glycogen phosphorylase activation
4. Glycogen phosphorylase
5. GPb versus GPa (1)
6. GPb versus GPa (2)
7. Reaction catalysed by glycogen phosphorylase
8. Adrenaline to phosphorylase signalling pathway
9. Phosphorylase kinase
10. Phosphorylase kinase catalytic subunit
11. Cryo-EM studies on phosphorylase kinase
12. The phosphorylase kinase model
13. Protein kinases regulate the cell cycle
14. CDK2 as a model system (1)
15. CDK2 as a model system (2)
16. Phosphothreonine acts as an organizing centre
17. Proline specificity in CDK2
18. Checkpoint controls of CDK2 in the cell cycle
19. Active CDK2 with ATP and substrate
20. CDK2 in action
21. The retinoblastoma protein and gene expression
22. P27kip1 - a Cdk inhibitor and activator
23. Cyclin E and cancer
24. STAT
25. Consequences of protein phosphorylation
26. References

Topics Covered

• Physical-chemical basis for phosphorylation
• Discovery
• Glycogen phosphorylase
• Signaling from adrenaline to phosphorylase
• Phosphorylase kinase still a challenge
• Regulation of the cell cycle by phosphorylation
• Cyclin dependent protein kinase 2 activation and inhibition
• Rb the guardian of the genome
• Control by p27 and cyclin E
• Summary of the structural consequences of phosphorylation

Links

Series:

• Protein Phosphorylation

Categories:

• Biochemistry

Talk Citation

Johnson, L.N. (2010, November 30). The structural basis for the modulation of protein function by protein phosphorylation [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/XRXJ4467.
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Publication History

• Published on November 30, 2010

Financial Disclosures

• Prof. Dame Louise N. Johnson has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.