• The Discovery of Protein Phosphorylation
• 45 min
  1. Phosphorylase and the origin of reversible protein phosphorylation

  • Prof. Edmond Fischer
• 21 min
  2. Three decades of protein phosphorylation and cancer: the identification and characterization of the src gene product

  • Prof. Raymond Erikson
• Protein Kinase Cascades
• 32 min
  3. Role of the PI 3-kinase signaling pathway in cell regulation and human disease

  • Prof. Lew Cantley
• The Modulation of Protein Function by Phosphorylation
• 33 min
  4. Two is the key to 14-3-3: dimeric mechanical signaling devices

  • Prof. Carol MacKintosh
• Protein Phosphatases
• 38 min
  5. Structure and mechanisms of protein phosphatases

  • Prof. David Barford
• 45 min
  6. Protein tyrosine phosphatases

  • Prof. Jack Dixon
• 49 min
  7. The regulation of MAP kinase signalling by dual-specificity protein phosphatases

  • Prof. Steve M. Keyse
• 22 min
  8. Protein phosphatase inhibitors: a distillation of cell signaling research and water toxicology

  • Prof. Carol MacKintosh
• The Structures of Protein Kinases
• 45 min
  9. Protein kinase structure, function and regulation

  • Prof. Susan Taylor
• 42 min
  10. The structural basis for the modulation of protein function by protein phosphorylation

  • Prof. Dame Louise N. Johnson
• Biological Systems that are Regulated by Reversible Phosphorylation
• 50 min
  11. Protein phosphorylation and the control of protein synthesis

  • Prof. Christopher Proud
• 62 min
  12. The role of phosphorylation in mediating cellular responses to DNA damage: the ATM-mediated DNA damage response

  • Prof. Yosef Shiloh
• 40 min
  13. Roles of AMPK in energy homeostasis and nutrient sensing

  • Prof. Grahame Hardie
• 56 min
  14. Serine kinases and T lymphocyte biology

  • Prof. Doreen Cantrell
• 30 min
  15. The interplay between protein phosphorylation and ubiquitylation in the NF-κB pathway

  • Prof. Zhijian 'James' Chen
• 58 min
  16. SMAD phosphorylation and the TGF-beta pathway

  • Prof. Joan Massagué
• Protein Kinases and Human Disease
• 58 min
  17. Function and regulation of the PDK1 kinase

  • Prof. Dario Alessi
• 63 min
  18. LKB1 pathway and its role in cancer

  • Prof. Dario Alessi
• 51 min
  19. WNK1 pathway and its role in regulating hypertension

  • Prof. Dario Alessi
• 33 min
  20. The hyperphosphorylation of tau and Alzheimer's disease

  • Prof. Michel Goedert
• Protein Kinases as Targets for the Development of Anti-Cancer Drugs
• 68 min
  21. PI3K/AKT signaling in cancer

  • Prof. Neal Rosen
• 37 min
  22. RAS and RAF signaling in melanoma: biology and therapies

  • Prof. Richard Marais
• 38 min
  23. The mTOR kinase as a target for anti-cancer drugs

  • Prof. David Sabatini
• Archived Lectures *These may not cover the latest advances in the field
• 51 min
  24. Modular protein-protein interactions provide a general mechanism to organize dynamic cellular systems

  • Prof. Tony Pawson
• 38 min
  25. AMP-activated protein kinase: regulating cellular and whole body energy balance

  • Prof. Grahame Hardie

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Chemically-diverse natural inhibitors of PPP (1)
3. Okadaic acid and microcystin binding kinetics
4. Similar 3D motifs within the PP1 active site
5. Microcystin - PP1 binding site
6. Microcystin bonds with a cysteine residue
7. Microcystin affinity chromatography (1)
8. Microcystin affinity chromatography (2)
9. PP inhibitors trap phosphorylated substrates
10. Protein phosphorylation regulates cellular events
11. PP2B is inhibited by cyclosporin and cyclophilin
12. Chemically-diverse natural inhibitors of PPP (2)
13. Cantharidin
14. Okadaic acid
15. Microcystins and nodularins
16. Microcystin contaminated water sources
17. Enzyme/microcystin interactions - how will it help
18. Microcystin - a legal paradox (1)
19. Microcystin - a legal paradox (2)
20. Microcystin poisonings
21. Causes of cyanobacterial blooms
22. Dundee center for water law policy and science
23. Concluding remarks

Topics Covered

• Toxic inhibitors of protein PPP family serine/threonine phosphatases
• Use of these compounds to characterize the functions and structures of PPP enzymes
• The natural ecological contexts of the toxins
• Okadaic acid and the shellfish industry
• Microcystin in freshwater cyanobacteria
• Contrasts in how microcystin in regarded legally by the security and water industries
• Attempts to understand global trends in microcystin

Links

Series:

• Protein Phosphorylation

Categories:

• Biochemistry

Talk Citation

MacKintosh, C. (2010, November 30). Protein phosphatase inhibitors: a distillation of cell signaling research and water toxicology [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 19, 2025, from https://doi.org/10.69645/JHPP7739.
Export Citation (RIS)

Publication History

• Published on November 30, 2010

Financial Disclosures

• Prof. Carol MacKintosh has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.