Mechanisms through which protein interactions modules, such as the SH2 domain, mediate the activation of specific signaling pathways by normal and oncogenic tyrosine kinases
The biological functions and biochemical properties of interaction domains including their roles in controlling protein localization, in recognition of post-translational modifications, in forming multi-protein complexes, and in regulating enzymatic function
The versatility of interaction domains, their potential utility in the evolution of new signaling pathways, and their exploitation by pathogenic proteins to rewire cellular behavior
Pawson, T. (2010, December 14). Modular protein-protein interactions provide a general mechanism to organize dynamic cellular systems [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 1, 2021, from https://hstalks.com/bs/1881/.
Published on December 14, 2010
Archived on May 31, 2018
Prof. Tony Pawson has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.