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1. Introduction
2. Phosphoinositide 3-kinase (PI3K) signaling
3. Class Ia PI3K's mediate growth factor signaling
4. Receptor tyrosine kinase signaling pathway
5. Logic network
6. Loss-of-function mutations in tumor suppressors
7. Sporadic mutations
8. Drug targets
9. Regulation of metabolism by PI3K AKT signaling
10. NVP BEZ235
11. Targets of BEZ235 (1)
12. Targets of BEZ235 (2)
13. Generation of mice with mutant PI3K p110a
14. Lung adenocarcinoma requires mutant PI3K
15. HIF-1alpha
16. Visualizing lung tumors using FDG PET
17. mTOR inhibition does not reduce tumor volume
18. Will a PI3K inhibitor kill K-Ras driven tumors?
19. AKT inhibition does not affect tumor size or activity
20. Effects of BEZ235 in K-Ras mutant tumors
21. BEZ235 specifically kills PI3K driven tumors
22. ARRY 886
23. PI3K with MEK inhibitors eradicates K-Ras tumors
24. Blocking the PI3K and MAP Kinase pathways
25. Inhibition of S6 kinase in K-Ras tumors
26. Summary
27. References

Topics Covered

• Phosphoinositide 3-kinase (PI3K) signaling
• Class Ia PI3K's and the mediation of growth factor signaling
• The receptor tyrosine kinase signaling pathway
• Loss-of-function mutations in tumor suppressors
• Sporadic mutations
• Drug targets
• Regulation of metabolism by PI3K AKT signaling
• Targets of the drug NVP BEZ235
• Generation of mice with mutant PI3K p110a
• How lung adenocarcinoma requires mutant PI3K
• HIF-1alpha
• Visualizing lung tumors using FDG PET
• How mTOR inhibition does not reduce tumor volume
• Will a PI3K inhibitor kill K-Ras driven tumors?
• How AKT inhibition does not affect tumor size or activity
• Effects of BEZ235 in K-Ras mutant tumors
• How BEZ235 specifically kills PI3K driven tumors
• The drug ARRY 886
• How PI3K with MEK inhibitors eradicates K-Ras tumors
• Blocking the PI3K and MAP Kinase pathways
• Inhibition of S6 kinase in K-Ras tumors

Links

Series:

• Protein Phosphorylation

Categories:

• Biochemistry
• Cell Biology

Talk Citation

Cantley, L. (2010, November 30). Role of the PI 3-kinase signaling pathway in cell regulation and human disease [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/ZQRQ1624.
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Publication History

• Published on November 30, 2010

Financial Disclosures

• Prof. Lew Cantley, Consultant: Novartis.