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Biomedical Basics

Immunodeficiencies

  • Created by Henry Stewart Talks
Published on February 26, 2026   4 min

A selection of talks on Clinical Practice

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The topic of immunodeficiencies will be explored through the types of immunodeficiencies, distinguishing between primary, genetic, and secondary acquired forms, and their impact on susceptibility to infections and autoimmune conditions. We will discuss how deficiencies in different components of the immune system lead to characteristic clinical patterns and review the hallmarks and diagnostic approach for these disorders. Finally, we will outline current treatment strategies, including supportive care, immunoglobulin replacement, stem cell transplantation, and advances in gene therapy, emphasizing the importance of early intervention and multidisciplinary care. Immunodeficiencies are disorders in which the immune system is inadequately developed or impaired. They are classified as either primary due to inherited genetic defects present from birth or secondary, acquired later in life from factors like infections, medications or diseases. Affected individuals are more prone to frequent, severe or unusual infections and may experience auto immunity, allergies, or malignancies. Early recognition and intervention are crucial for better outcomes. Primary immunodeficiencies are rare genetic disorders that disrupt one or more aspects of the immune system involving B cells, T cells, both combined, vagocytes or complement. Secondary or acquired immunodeficiencies are more common and result from factors like HIV infection, malnutrition, chemotherapy, organ transplantation, or certain medications.

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