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Navigable Slide Index

1. Introduction
2. Alzheimer disease pathology
3. Tau-containing tangles and related lesions
4. Aberrant splicing of tau gene can cause tauopathy
5. Pathogenic mechanisms in tauopathy
6. Targets for drug development in the tauopathies
7. Reduction of tau by immunotherapy
8. Phospho-tau as a target
9. GSK3 inhibition via lithium
10. Tau-microtubule interaction as a target
11. Degradation of abnormal tau as a target
12. Disaggregation of tau as a target
13. Enhanced neuroprotection as a target
14. Summary

Topics Covered

• Tauopathies
• Alzheimer's Disease and frontal temporal lobe dementia
• Pathogenic mechanisms
• Therapeutic approaches for the tauopathies

Links

Series:

• Alzheimer's Disease
• Drug Discovery and Development in the Neurosciences

Categories:

• Clinical Practice
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Duff, K. (2010, August 26). Pathogenic mechanisms and therapeutic approaches for the tauopathies [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 21, 2024, from https://doi.org/10.69645/CVYV4161.
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Publication History

• Published on August 26, 2010

Financial Disclosures

• Prof. Karen Duff has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.