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1. Introduction
2. Alzheimer's disease
3. Vaccination against AD
4. Radial arm water maze
5. Vaccination prevents memory deficits in mice
6. Memory deficits correlate with amyloid-beta levels
7. Clinical trial of anti-amyloid-beta vaccine
8. Antibodies against amyloid-beta are efficacious
9. Where to go?
10. Mechanisms of antibody-mediated clearance
11. Catalytic fibril dissolution
12. Opsonization/Phagocytosis
13. Peripheral sink hypothesis
14. Administration of antibodies into old mice
15. Diffuse and compact amyloid deposits
16. Anti-amyloid-beta antibody labels plaques
17. Antibodies decrease amyloid-beta immunostaining
18. Antibodies reduce congophilic deposits
19. Parenchymal and vascular amyloid deposits
20. Anti-amyloid-beta increases vascular amyloid
21. Microhemorrhages increase with immunization
22. Behavioral benefits are retained
23. Immunotherapy may have a problem
24. A possible solution
25. Deglycosylated 2H6 does not activate microglia
26. Deglycosylated anti-amyloid-beta 2H6
27. Systemic administration experimental design
28. Antibodies reverse cognitive decline
29. 2H6 causes a greater increase in vascular amyloid
30. Intact 2H6 results in more microhemorrhages
31. Key points
32. Histopathology - Elan-Wyeth phase 1 trial
33. Bapineuzumab phase 1
34. Bapineuzumab phase 2 trial results
35. Current trials of Amyloid-beta immunotherapy
36. Prospects for immunotherapy

Topics Covered

• Alzheimer's Disease
• Immunization with amyloid-beta (A-beta)
• Radial arm water maze
• Clinical trial of anti-A-beta vaccine
• Mechanisms of antibody-mediated A-beta clearance
• Catalytic fibril dissolution
• Peripheral sink hypothesis
• Systemic administration of anti-A-beta antibodies into old APP transgenic (Tg) mice
• Diffuse and compact amyloid deposits
• Systemic anti-A-beta antibody
• Parenchymal and vascular amyloid deposits
• Microhemorrhages
• A possible solution to the problems of immunotherapy
• Systemic administration experimental design
• Intact and deglycosylated antibodies reverse cognitive decline
• Current clinical trials of A-beta immunotherapy
• Prospects for immunotherapy

Links

Series:

• Alzheimer's Disease

Categories:

• Clinical Practice
• Immunology
• Neuroscience

Therapeutic Areas:

• Immunology & Inflammation
• Neurology

Talk Citation

Morgan, D. (2010, August 26). Immunotherapy as an approach to treating Alzheimer's disease [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved March 31, 2023, from https://hstalks.com/bs/1813/.
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Publication History

• Published on August 26, 2010

Financial Disclosures

• Prof. David Morgan has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.