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1. Introduction
2. Outline of presentation
3. Role of mitochondria in muscle contraction
4. ATP use in skeletal muscle
5. Aerobic skills and mitochondrial oxidative capacity
6. Mitochondrial content predicts muscle fatigue
7. Mitochondrial capacity and muscle capacity
8. Mitochondrial content increases with muscle use
9. Capillary surface area
10. Skeletal muscle contractile performance and aging
11. Whole body aerobic capacity declines with aging
12. Muscle mass declines with aging
13. Functional deficits in aged skeletal muscle
14. Pump-perfused rat hind limb model
15. Mass-specific muscle oxygen declines with age
16. Effect of aging on mitochondrial oxidative capacity
17. Oxidative capacity of muscle declines with aging
18. Structural capacity for oxygen delivery and aging
19. Reductions in muscle aerobic function with aging
20. Mitochondrial oxidative capacity in sarcopenia
21. Mitochondrial dysfunction in aged muscle
22. Mitochondria and ROS production
23. Mitochondrial ROS production and aging
24. Impaired coupling
25. Oxygen cost of muscle contractions and aging
26. Decline in some mitochondrial enzyme activities
27. Oxidative capacity per mitochondrion and aging
28. Changes in mitochondrial proetin abundance
29. Mechanisms of mitochondrial dysfunction in aging
30. Factors contributing to mitochondrial dysfunction
31. Aging and mtDNA damage (1)
32. Aging and mtDNA damage (2)
33. Mitochondrial enzymes and oxidative damage (1)
34. Mitochondrial enzymes and oxidative damage (2)
35. Mitochondrial protein degradation and aging
36. Mitochondrial protein synthesis rate and aging
37. Mitochondrial biogenesis and aging
38. Declines in ETC gene expression (1)
39. Declines in ETC gene expression (2)
40. Why does mitochondrial biogenesis decline?
41. Summary

Topics Covered

• Role of mitochondria in muscle performance
• Changes in skeletal muscle contractile function with aging
• Effect of aging on mitochondrial oxidative capacity and its consequences
• Mitochondrial dysfunction in aged muscle
• Mechanisms contributing to mitochondrial dysfunction in aged muscles

Links

Series:

• Mitochondrial Biogenesis

Categories:

• Biochemistry
• Cell Biology

Talk Citation

Hepple, R. (2007, October 1). Muscle mitochondrial function and biogenesis with aging [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/TZVC7462.
Export Citation (RIS)

Publication History

• Published on October 1, 2007
• Archived on October 28, 2018

Financial Disclosures

• Dr. Russell Hepple has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.