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1. Introduction
2. Mitochondria are highly multifunctional organelles
3. Oxidative phosphorylation (OP)
4. The mitochondrial genome
5. Aging is the accumulation of damage
6. What types of damage are there in aging?
7. Types of damaged cells
8. OP-negative cells accumulate in vivo during aging
9. Cells can sometimes survive without OP in vitro
10. OP-negative cells, classical view
11. Complex IV
12. Complex II
13. OP-negative cells, classical view: no TCA activity!
14. Plasma stabilisation of OP(-), TCA(+) cells' redox
15. The plasma membrane redox system (PMRS)
16. Age-related change in need of an explanation
17. The PMRS is poorly characterised
18. Free radical production model
19. Mitochondrial electron import/export implications
20. Possible consequences for aging
21. The connection to mitochondrial biogenesis
22. Mutant mtDNA is clonal - usually deletions
23. Mitochondria divide - even in non-dividing cells
24. Division must be balanced by destruction
25. Candidate mechanisms for clonal expansion
26. "Survival of the Slowest"
27. Options for intervention
28. Restoring non-mutant mtDNA?
29. Making mtDNA superfluous
30. Growth curves of 11-11 and ZR11
31. Allotopic expression
32. Mitochondrial protein import
33. TIM23 cannot import highly hydrophobic proteins
34. TIM22 imports extremely hydrophobic proteins
35. Allotopic expression must use TIM23
36. Reducing hydrophobicity
37. Conclusions

Topics Covered

• Oxidative phosphorylation
• The mitochondrial DNA
• Aging as the accumulation of damage
• Types of aging damage
• Types of damaged cells
• Survival of cells lacking oxidative phosphorylation
• The plasma membrane redox system
• Reductive hotspot hypothesis
• "Survival of the slowest" hypothesis
• Allotopic expression
• Hydrophobicity prevents allotopic expression of mitochondrially-encoded proteins
• Ways to make these proteins allotopically expressible

Links

Series:

• Mitochondrial Biogenesis

Categories:

• Biochemistry
• Cell Biology

Talk Citation

de Grey, A. (2016, November 18). Possible roles of mitochondrial biogenesis in aging [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved May 31, 2025, from https://doi.org/10.69645/TJDI8425.
Export Citation (RIS)

Publication History

• Published on October 1, 2007
• Reviewed on November 18, 2016
• Archived on May 28, 2025

Financial Disclosures

• Dr. Aubrey de Grey has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.