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Printable Handouts
Navigable Slide Index
- Introduction
- Lecture structure
- Bone structure
- Cross talk between osteoblasts and osteoclasts
- M-CSF cooperates with RANKL
- EphrinB2 - EphB4 interaction
- Immune system and bone: common regulators
- Direct influence of the immune system on bone
- IL17, IL1, IL6 and TNF are pro-osteoclastogenic
- DKK1 and SOST inhibit osteoblast proliferation
- Ig-like receptors induce osteoclastogenesis
- PAMPs and TLRs modulate osteoclastogenesis
- Osteoimmunoendocrinology
- PPAR-gamma is a negative regulator
- Effects of immune activation on bone structure
- Arthritis disrupts bone structure and biomechanics
- Anti TNF treatments stop bone erosions
- Anti TNF treatments decrease osteoclastogenesis
- Conclusions
- Take-home messages
Topics Covered
- Osteoimmunology
- Bone structure
- Crosstalk between osteoblasts and osteoclasts
- Immunoregulation of bone
- Direct influence of the immune system on bone
- Osteoimmunoendocrinology
- Effects of immune activation on bone structure
Talk Citation
Fonseca, J.E. and Caetano-Lopes, J. (2010, July 21). Osteoimmunology [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 3, 2024, from https://doi.org/10.69645/TZWU5359.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. João Eurico Fonseca has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
- Ms. Joana Caetano-Lopes has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.