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1. Introduction
2. Cytosine methylation
3. DNA methylation in mammals
4. CpG islands associated genes
5. Re-setting methylation patterns
6. Reprogramming the DNA methylome
7. The 'epigenetic' code
8. The basic unit of chromatin is the nucleosome
9. Histone 'code' (1)
10. Histone 'code' (2)
11. Setting and re-setting the epigenetic code
12. DNA methylation and histone modifications
13. Organization of the 'epigenome'
14. DNA hypomethylation in cancer
15. DNA hypermethylation in cancer
16. Knudsons hypothesis revisited
17. Epigenetic silencing in cancer
18. Gene targets of aberrant DNA methylation
19. Polycomb and aberrant DNA methylation
20. Polycomb-mediated repression
21. Role of Polycomb proteins in stem cells
22. Polycomb reprogramming during tumorigenesis
23. Polycomb repression and methylation in cancer
24. Reduction of epigenetic plasticity
25. DNA methylation and cancer stem cells
26. CpG island methylator phenotype - 'CIMP'
27. CIMP exhibiting Gliomas
28. Factors driving aberrant DNA methylation
29. Altered DNA methylation in cancer and miRNAs
30. Genetic basis for epigenetic alterations in cancer
31. Epigenetic silencing as a therapeutic strategy
32. Clinically active DNA methylation inhibitors
33. Exploiting DNA methylation in the clinic
34. Methylation of the MGMT gene
35. Summary (1)
36. Summary (2)
37. Acknowledgements

Topics Covered

• DNA methylation in cancer
• Overview of DNA methylation in human cells
• Relationshoip of DNA methylation and chromatin structure
• Contribution of hypo/hypermethylation to tumorigenesis
• Mechanisms underlying altered DNA methylation patterns in cancer
• miRNAs as effectors and targets of aberrant DNA methylation in cancer
• Cancer methylation biomarkers
• Reversing DNA methylation in cancer therapy

Links

Series:

• DNA Methylation

Categories:

• Cancer
• Cell Biology
• Genetics & Epigenetics

Therapeutic Areas:

• Oncology

Talk Citation

Publication History

• Published on March 3, 2011

Financial Disclosures

• Prof. Paula Vertino has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.