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About Biomedical Basics
Biomedical Basics are AI-generated explanations prepared with access to the complete collection, human-reviewed prior to publication. Short and simple, covering biomedical and life sciences fundamentals.
Topics Covered
- Second messengers in cell signaling
- CAMP, IP3, calcium generation
- Signal transduction pathways
- Amplification and termination of signals
- Roles of cAMP, IP3, and calcium
- Cross-regulation of second messenger pathways
- Cell function and disease relevance
Links
Categories:
Therapeutic Areas:
Talk Citation
(2026, January 28). Second messengers: cAMP, IP3, calcium [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved February 9, 2026, from https://doi.org/10.69645/QUNC2306.Export Citation (RIS)
Publication History
- Published on January 28, 2026
Financial Disclosures
A selection of talks on Cardiovascular & Metabolic
Transcript
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0:00
This presentation will examine
second messengers with
a focus on the essential roles
of three major
second messengers,
Camp IP three and calcium
ions in cellular signaling.
We will examine how
each messenger is
generated in response
to external signals,
activates specific
intracellular pathways,
and orchestrates diverse
cellular processes.
By discussing their interactions
and regulatory mechanisms,
we will highlight the
complexity and importance of
second messenger systems in
cell function and disease.
Today, we'll explore
the vital roles
of three second messengers,
cyclic AMP E camp in
oscitl one, four,
five trisphosphate, IP three,
and calcium ions in
cellular signaling.
Second messengers
relay signals from
cell surface receptors
to internal targets,
amplifying and
integrating information
to drive proper
cellular responses.
By focusing on CAP,
IP three, and calcium,
we see how external cues
are swiftly converted into
specific intracellular
actions through
coordinated signal
transduction pathways.
Let's first consider CAMP,
the classic second messenger
discovered by Earl Sutherland.
Camp production begins when
a signal like adrenaline
binds to a G protein coupled
receptor on the membrane,
activating a G protein
that stimulates
a dnelial cyclase to
convert ATP into cAMP.
Camp activates protein kinase A,
which phosphorylates
proteins, promoting
glycogen breakdown, and
inhibiting synthesis.
Camp's signal is
amplified dramatically,