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This talk introduces MAP kinase
and PI three K act pathways,
using it as a basis for
further exploration of
the roles of the MAP
kinase and PI three K Act,
signaling pathways in regulating
cell growth, survival,
and metabolism, and
their significance in
both normal physiology and
disease, particularly cancer.
We will examine the
molecular mechanisms
of pathway activation,
downstream effects on
cellular functions,
and the importance of
regulatory feedback loops.
The interplay and cross talk
between these
pathways and how they
contribute to cancer
development and
therapy resistance will
also be discussed.
Finally, we will consider
therapeutic strategies that
target these pathways,
focusing on the challenges and
opportunities for
combination treatments.
We will explore two
major signaling pathways
central to cellular responses,
the MAP kinase and PI
three K Act pathways.
These highly conserved
pathways are
critical for regulating
cell growth,
survival, metabolism,
and differentiation.
Their importance spans from
normal physiology to
disease, especially cancer.
A examination of
their activation by
growth factors and
their orchestration of
cellular processes
offers insight into
biology and potential
therapeutic strategies.
The map kinase or
mitogen activated protein
kinase pathway is
a multi step cascade
transmitting signals
from receptor tyrosine
kinases to the nucleus.
It starts with a growth
factor binding its receptor,
activating RS, a small GTPase.
