Please wait while the transcript is being prepared...
0:00
This presentation will examine
extracellular matrix
with a focus on
the fundamental structure and
dynamic roles of the
extracellular matrix,
ECM in multicellular organisms.
We will examine the
main classes of
ECM macromolecules and
their functional diversity,
distinguish between the basement
membrane and
interstitial matrix,
and explore how
the ECM regulates
cell behavior through
biochemical and mechanical cues.
Additionally, we will discuss
the critical interactions
between ECM components and
cell surface receptors,
such as integrins and how
these relationships impact
tissue organization,
development, repair and disease.
The extracellular matrix or
ECM is an intricate network of
secreted macromolecules
occupying the space
between cells in all
multicellular organisms,
rather than being a
passive scaffold,
the ECM is a dynamic,
highly regulated component
of tissue architecture.
It provides the physical
and biochemical environment
necessary for cellular survival,
proliferation and
differentiation,
while its composition and
organization vary by tissue,
development, and
physiological condition.
ECM is composed of three
main macromolecule classes,
fibrous proteins, proteoglycans,
and multi adhesive
glycoproteins.
Collagen, the most
abundant ECM protein,
imparts tensile
strength and forms
triple heliss,
fibrils, and fibers.
Elastin provides elasticity for
tissues like skin and lungs.
Proteoglycans, linked to
glycosaminoglycan chains,
