RNA interference

This presentation will examine RNA interference with a focus on the mechanism of RNA interference, RNAI, its discovery, and its fundamental role in gene regulation and cellular defense. We'll outline the roles of small interfering RNAs and micro RNAs and how they guide silencing complexes to specific messenger RNAs. The significance of RNAI in development, disease, and its application in biotechnology and medicine will be discussed, along with therapeutic advances and challenges in specificity and delivery. Finally, we'll highlight ongoing efforts to overcome these obstacles, expanding the potential of RNAI in research and treatment. We will explore RNA interference or RNAI. Discovered just over two decades ago, RNAI is a natural mechanism by which cells regulate gene expression and defend themselves, especially against genomic parasites like viruses and transposable elements. The core of RNAI involves small RNA molecules that recognize specific messenger RNAs and silence their expression. RNAI is widely used in research, biotechnology, and medicine and shows promise for human disease treatment. At the heart of RNAI are two families of small RNA molecules, small interfering RNAs and microRNAs. Both guide the RNA induced silencing complex. Double stranded RNA from viruses or endogenous genes is processed by DCR into 21 to 23 nucleotide sRNAs.