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Printable Handouts
Navigable Slide Index
- Introduction
- Molecular imaging to guide therapy: outline
- Anatomic vs. functional imaging
- Functional imaging modalities
- Positron emission tomography (PET)
- PET/CT
- Why radiotracer imaging?
- Existing cancer imaging paradigm
- FDG PET detects mammary nodal metastases
- A new paradigm for cancer imaging
- Imaging and targeted therapy
- Emerging cancer imaging paradigm
- Localize and characterize disease sites
- Image acquisition and quantitative analysis
- Choosing the right patients
- ER and breast cancer endocrine therapy
- FES: PET estrogen receptor (ER) imaging
- Validation: ER+ vs. ER- tumors
- PET provides estimate of ER expression
- FES predicts response to hormonal therapy (1)
- FES predicts response to hormonal therapy (2)
- Imaging hypoxia
- FMISO PET predicts outcome for GBM patients
- Hypoxia as a target for radiotherapy planning
- Imaging to direct hypoxia-specific treatment
- Choosing the right drug
- Resistance due to altered drug transport
- Imaging P-gp activity in vivo in humans
- FES PET measures pharmacodynamics
- Getting the right result
- Events in response to successful cancer therapy
- Thymidine incorporation pathways
- PET imaging pre- and post one cycle of Rx
- Thymidine analogs for cell proliferation imaging
- Early response measured by FLT PET
- FLT brain tumor imaging to measure response
- Bone metastasis response monitoring (1)
- Bone metastasis response monitoring (2)
- Change in FDG SUV correlates with response
- FDG uptake predicts outcome of breast cancer
- FDG PET/CT to monitor breast cancer response
- FDG PET vs. bone scan
- Predicting the outcome
- Neo-adjuvant therapy - PET assessment
- PET predicts survival after neo-adjuvant therapy
- Molecular imaging - measuring in vivo biology
- Changes in cancer metabolism and blood flow
- Results: multivariate DFS
- Flow-metabolism mismatch and poor response
- Match predicts path CR, mismatch: early relapse
- Metabolism-flow mismatch predicts poor outcome
- Altered metabolism and myocardial viability
- Glycolysis and angiogenesis
- Future directions
- ACRIN experimental imaging sciences committee
- Acknowledgements: UW PET cancer P01
- Breast cancer imaging research group
- Acknowledgements - collaborators
Topics Covered
- Anatomic vs. functional imaging
- Functional imaging modalities
- PET/CT
- Radiotracer imaging
- Existing cancer imaging paradigm
- A new paradigm for cancer imaging
- Imaging and targeted therapy
- Biomarker imaging
- ER expression and breast cancer endocrine therapy
- Hypoxia-specific treatment
- Biologic events in response to successful cancer therapy
- Thymidine incorporation pathways
- Bone metastasis response monitoring
- FDG PET vs. bone scan
- Neo-adjuvant therapy of breast cancer
- Molecular imaging is a tool for measuring in vivo biology
- Changes in breast cancer metabolism and blood flow predict pathologic response
- Clinical trial of novel molecular imaging probes for cancer
- ACRIN experimental imaging sciences committee
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Mankoff, D. (2010, September 29). Clinical applications of molecular imaging: imaging to guide cancer therapy [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved January 28, 2021, from https://hstalks.com/bs/1673/.Publication History
Financial Disclosures
- Prof. David Mankoff has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Clinical applications of molecular imaging: imaging to guide cancer therapy
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