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Navigable Slide Index

1. Introduction
2. Primate evolution
3. Human characteristics
4. Examples of "human-specific" genes
5. Mechanisms underlying genome evolution
6. Gene duplication and evolutionary change
7. Exceptional duplicated regions
8. Identifying evolutionarily recent duplicated sequen.
9. Interhominoid cDNA aCGH
10. Experimental design
11. Caryoscope image of interhominoid aCGH data
12. TreeView image of interhominoid aCGH data
13. Genes showing lineage-specific CN changes
14. Interhominoid cDNA aCGH results
15. Summary of human/great ape aCGH results
16. Regions with active copy number changes
17. Clusters of hominoid LS copy number changes
18. Changes in regions associated with diseases
19. Gorilla-specific increase in FGFR3 copy number
20. Data from additional five primate species
21. Human lineage-specific amplification of AQP7
22. Chromosome 9 view showing gaps / duplications
23. Orangutan-specific amplification of the CA1 gene
24. Copy number variation in HLA-related genes
25. Dating primate LS gene copy number changes
26. Identifying candidates for LS traits
27. The DUF1220 repeat unit
28. InterPro-predicted DUF1220-containing proteins
29. BLAT-based estimates of DUF1220 copy number
30. Sequences encoding DUF1220 domains
31. Summary
32. Primate aCGH caveats
33. Acknowledgements
34. Relevant Sikela lab publications
35. Additional references

Topics Covered

• Primate evolution
• Human characteristics
• Molecular mechanisms underling genome evolution
• Gene duplication and evolutionary change
• Interhominoid cDNA array-based comparative genomic hybridization
• Major clusters of hominoid lineage
• Primate gene copy number changes
• Primate lineage-specific gene copy number variation
• Primate aCGH caveats

Links

Series:

• Copy Number Variation

Categories:

• Genetics & Epigenetics

Talk Citation

Sikela, J. (2010, June 10). Gene copy number variation in human and primate evolution [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 16, 2024, from https://hstalks.com/bs/1659/.
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Publication History

• Published on June 10, 2010

Financial Disclosures

• Prof. James Sikela has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.