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- Fundamentals of Evolution and Medicine
-
50 min
1. Evolutionary medicine- Prof. Randolph Nesse
-
38 min
2. Evolution and medicine: from the perspective of an evolutionary biologist- Prof. Stephen C. Stearns
-
31 min
3. Developmental plasticity, evolution and the origins of disease- Dr. Mary Jane West-Eberhard
- Evolutionary Genetics
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47 min
4. Genetic variation and human disease- Dr. David Houle
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65 min
-
46 min
6. Ecogenetics, evolutionary biology and human disease- Prof. Gilbert Omenn
-
24 min
7. Race in genetics and medicine- Prof. Jeffrey Long
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46 min
8. Health disparities in common complex diseases: a role for genetics?- Dr. Kathleen Barnes
- Infectious Disease
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44 min
-
39 min
10. Evolutionary arms races- Prof. Mark Pagel
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43 min
11. Antibiotic resistance and hospital-acquired infection- Dr. Carl Bergstrom
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36 min
12. Evolution of drug resistance- Dr. Pleuni Pennings
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34 min
13. Evolution of virulence: malaria, a case study- Prof. Andrew Read
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38 min
14. Infection and chronic disease- Prof. Paul Ewald
- Defenses
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36 min
15. Fever and related defenses- Prof. Matthew Kluger
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45 min
16. The evolutionary ecology of immunity- Prof. Paul Schmid-Hempel
- Novel Environmental Factors
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39 min
17. What did humans evolve to eat? evolutionary perspectives on human nutritional health- Prof. William R. Leonard
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45 min
-
42 min
19. The paleolithic lifestyle and prevention of chronic disease- Prof. S. Boyd Eaton
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49 min
-
31 min
-
31 min
22. Diseases of civilization: an evolutionary legacy- Prof. Alan Weder
- Problems Arising From Constraints and Trade-Offs
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51 min
23. Aging and evolutionary medicine- Prof. Linda Partridge
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45 min
24. Human aging and menopause- Prof. Kristen Hawkes
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32 min
25. Why we cook with spices: preventative darwinian medicine- Prof. Paul Sherman
- Sex and Reproduction
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32 min
26. Setting the second stage: the evolution of menopause & post-reproductive life- Prof. Lynnette Sievert
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44 min
27. Evolutionary obstetrics- Prof. Wenda Trevathan
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41 min
28. Sex differences in mortality- Dr. Daniel Kruger
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46 min
29. The endocrinology of human life history transitions- Prof. Peter Ellison
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43 min
30. Genetic conflicts in human pregnancy- Prof. David Haig
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57 min
31. Environmental effects on human reproduction- Prof. Gillian Bentley
- Cancer
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54 min
32. A darwinian eye view of cancer- Prof. Mel Greaves
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56 min
33. Viruses and cancer- Prof. Robin Weiss
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38 min
34. Connecting aging and cancer through the lens of evolution- Prof. James DeGregori
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44 min
35. Evolutionary dynamics in cancer control and cure- Dr. Bob Gatenby
- Specific Body Systems
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44 min
36. Hard tissue biology in human health and evolution: enamel biology- Prof. Timothy Bromage
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19 min
37. Hard tissue biology in human health and evolution: bone biology- Prof. Timothy Bromage
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46 min
38. Hard tissue biology in human health and evolution: craniofacial biology- Prof. Timothy Bromage
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26 min
39. Hard tissue biology in human health and evolution: life history and chronobiology- Prof. Timothy Bromage
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53 min
40. Lung biology and lung disease- Prof. John S. Torday
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30 min
41. The evolutionary web of life- Prof. John S. Torday
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32 min
42. Evolutionary considerations and the endothelium- Dr. William Aird
- Mental Disorders
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38 min
43. Evolutionary psychiatry- Prof. Randolph Nesse
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48 min
44. Evolutionary behavioural genetics and mental disorders- Dr. Matthew Keller
- Questions and Answers
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57 min
45. Audience questions about evolution and medicine- Prof. Randolph Nesse
- Paediatrics
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41 min
46. Evolutionary pediatrics- Dr. Paul Turke
- Microbiome
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49 min
47. Evolution, the microbiome, and human health- Dr. Joe Alcock
- Archived Lectures *These may not cover the latest advances in the field
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42 min
48. The hygiene hypothesis- Prof. Graham Rook
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26 min
49. Mapping motivations: evolutionary health promotion- Dr. Valerie Curtis
- Dr. Robert Aunger
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16 min
50. Evolutionary biology of depression- Prof. Lewis Wolpert
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52 min
51. Evolutionary genetic epidemiology- Prof. Nicholas Schork
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65 min
52. Mental disorders in the light of evolutionary biology- Prof. Randolph Nesse
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59 min
53. Evolution: medicine's missing basic science- Prof. Randolph Nesse
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47 min
54. Environmental effects on human reproduction- Prof. Gillian Bentley
Printable Handouts
Navigable Slide Index
- Introduction
- Mental disorders (MDs)
- Example: schizophrenia
- Paradox of common, harmful, heritable MDs
- Outline
- Mental disorders run in families
- Classical twin design
- Twin designs
- Twin design example: schizophrenia
- Adoption designs (1)
- Adoption designs (2)
- Adoption design example: schizophrenia
- Genetic effects on mental disorder risk
- Heritability
- Two types of heritability
- Meaning of low heritability
- Meaning of high heritability
- The evolutionary paradox of heritable MDs
- Heritability and prevalence of mental disorders (1)
- Heritability and prevalence of mental disorders (2)
- Deleterious mutations
- Heritability and prevalence of mental disorders (3)
- Prevalence of MDs vs. other genetic disorders
- Possible explanations to the paradox
- Four non-resolutions to the paradox
- Three better resolutions to the paradox
- Neutral hypothesis of MD alleles
- Gene-environment interaction and depression
- Problems with neutral explanation
- Balancing selection hypothesis of MD alleles
- Frequency dependent selection (1)
- Frequency dependent selection (2)
- Heterozygote advantage
- Heterozygotes cannot 'breed true'
- Byproducts of heterozygous advantage
- Predictions of heterozygote advantage
- Problems with balancing selection hypothesis
- Polygenic mutation-selection hypothesis (1)
- Polygenic mutation-selection hypothesis (2)
- Deleterious mutations in the brain
- The individually effect of these mutations
- The cumulative effect of these mutations
- Perception of these underlying dimensions
- Different distribution of behaviours
- Mental disorders vs. single gene disorders
- Importance of mutation-selection in MDs
- Inbreeding reveals full recessive genetic effects
- Brain damage increases risk to common MDs
- MDs are probably highly polygenic
- Problems with mutation-selection hypothesis
- Conclusions (1)
- Conclusions (2)
- Thanks
Topics Covered
- Ways of assessing heritability in humans: twin and adoption designs
- The evolutionary paradox of common, heritable mental disorders
- Possible resolutions to the paradox: balancing selection, neutral mutation and polygenic mutation-selection balance
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Keller, M. (2007, October 1). Evolutionary behavioural genetics and mental disorders [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved January 15, 2025, from https://doi.org/10.69645/XENO9189.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Matthew Keller has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Evolutionary behavioural genetics and mental disorders
Published on October 1, 2007
48 min
