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- Basic Concepts
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1. Molecular structure of the human genome
- Prof. Jonathan Wolfe
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2. Introduction to mutation and disease
- Prof. Jonathan Wolfe
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3. Introduction to genetic diseases
- Prof. Jonathan Wolfe
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4. Historical introduction to human diversity I
- Prof. Dallas Swallow
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5. Historical introduction to human diversity II
- Prof. Dallas Swallow
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6. Introduction to cytogenetics 1
- Dr. Sioban SenGupta
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7. Introduction to cytogenetics 2
- Dr. Sioban SenGupta
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8. Introduction to cytogenetics 3
- Dr. Sioban SenGupta
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9. The Y-chromosome
- Prof. Mark Jobling
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10. Mitochondrial DNA, molecular genetics and human mitochondrial diseases
- Prof. Immo Scheffler
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11. Mechanisms of DNA repair by recombination
- Prof. James Haber
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12. Techniques utilized in molecular genetics
- Dr. Cecil Lewis
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13. Genome mapping
- Dr. Simon Gregory
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14. Copy number variation
- Dr. Ömer Gökçümen
- Genetics and Disease
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15. Genetic association studies
- Prof. David Balding
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16. Quantitative genetics and multifactorial inheritance
- Dr. Lara Bauman
- Human Evolutionary Genetics
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17. Population genetics
- Dr. Murray P. Cox
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18. Inference on human history through DNA
- Prof. Guido Barbujani
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19. Human adaptation
- Prof. Rasmus Nielsen
- Specialized Topics
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20. Accessing and using ENCODE data
- Prof. Peggy Farnham
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21. Pharmacogenetics
- Prof. Ann Daly
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22. Genetics in forensics
- Dr. Angel Carracedo
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23. The development and evolution of human gene therapy
- Prof. Theodore Friedmann
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24. Next generation sequencing technologies
- Dr. Krishna Veeramah
Printable Handouts
Navigable Slide Index
- Introduction
- Pharmacogenetics
- Pharmacogenomics
- Pharmacogenetics: brief history
- Specific examples to be considered
- Debrisoquine (CYP2D6) polymorphism
- Debrisoquine polymorphism: studies on phenotype
- Cytochromes P450
- Molecular basis of CYP2D6 polymorphism
- Poor metabolism and CYP2D6 polymorphisms
- Copy number variants in CYP2D6
- Number of CYP2D6 genes and nortryptiline
- Tamoxifen and CYP2D6
- CYP2D6 and codeine
- Ultrarapid metabolizers and codeine
- CYP2C9
- Functional effect of CYP2C9 alleles
- Warfarin
- Vitamin K cycle
- CYP2C9 genotypes and warfarin
- Warfarin dose requirement
- Vitamin K epoxide reductase
- VKORC1 polymorphisms (1)
- VKORC1 polymorphisms (2)
- CYP2C9/VKORC1 genotype warfarin dose
- Warfarin and pharmacogenetics
- Association study on warfarin dose requirement
- Methyltransferases
- Thiopurine S-methyltransferase (TPMT)
- TPMT polymorphism (1)
- TPMT polymorphism (2)
- Idiosyncratic adverse drug reactions
- Simvastatin myopathy
- Flucloxacillin-induced liver injury
- Summary
- References
Topics Covered
- Definition and history
- CYP2D6 polymorphism
- Pharmacogenetics of warfarin
- Thiopurine methyltransferase
- Genetics susceptibility to adverse drug reactions
Links
Series:
Categories:
Talk Citation
Daly, A. (2009, December 28). Pharmacogenetics [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved March 31, 2023, from https://hstalks.com/bs/1581/.Export Citation (RIS)
Publication History
Financial Disclosures
- Professor Ann Daly has no commercial/financial relationships to disclose.