• Basic Concepts
• 19 min
  1. Molecular structure of the human genome

  • Prof. Jonathan Wolfe
• 31 min
  2. Introduction to mutation and disease

  • Prof. Jonathan Wolfe
• 26 min
  3. Introduction to genetic diseases

  • Prof. Jonathan Wolfe
• 26 min
  4. Historical introduction to human diversity I

  • Prof. Dallas Swallow
• 28 min
  5. Historical introduction to human diversity II

  • Prof. Dallas Swallow
• 23 min
  6. Introduction to cytogenetics 1

  • Dr. Sioban SenGupta
• 15 min
  7. Introduction to cytogenetics 2

  • Dr. Sioban SenGupta
• 16 min
  8. Introduction to cytogenetics 3

  • Dr. Sioban SenGupta
• 42 min
  9. The Y-chromosome

  • Prof. Mark Jobling
• 42 min
  10. Mitochondrial DNA, molecular genetics and human mitochondrial diseases

  • Prof. Immo Scheffler
• 66 min
  11. Mechanisms of DNA repair by recombination

  • Prof. James Haber
• 26 min
  12. Techniques utilized in molecular genetics

  • Dr. Cecil Lewis
• 36 min
  13. Genome mapping

  • Dr. Simon Gregory
• 35 min
  14. Copy number variation

  • Dr. Ömer Gökçümen
• Genetics and Disease
• 45 min
  15. Genetic association studies

  • Prof. David Balding
• 42 min
  16. Quantitative genetics and multifactorial inheritance

  • Dr. Lara Bauman
• Human Evolutionary Genetics
• 34 min
  17. Population genetics

  • Dr. Murray P. Cox
• 59 min
  18. Inference on human history through DNA

  • Prof. Guido Barbujani
• 37 min
  19. Human adaptation

  • Prof. Rasmus Nielsen
• Specialized Topics
• 44 min
  20. Accessing and using ENCODE data

  • Prof. Peggy Farnham
• 44 min
  21. Pharmacogenetics

  • Prof. Ann Daly
• 33 min
  22. Genetics in forensics

  • Dr. Angel Carracedo
• 29 min
  23. The development and evolution of human gene therapy

  • Prof. Theodore Friedmann
• 33 min
  24. Next generation sequencing technologies

  • Dr. Krishna Veeramah

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Pharmacogenetics
3. Pharmacogenomics
4. Pharmacogenetics: brief history
5. Specific examples to be considered
6. Debrisoquine (CYP2D6) polymorphism
7. Debrisoquine polymorphism: studies on phenotype
8. Cytochromes P450
9. Molecular basis of CYP2D6 polymorphism
10. Poor metabolism and CYP2D6 polymorphisms
11. Copy number variants in CYP2D6
12. Number of CYP2D6 genes and nortryptiline
13. Tamoxifen and CYP2D6
14. CYP2D6 and codeine
15. Ultrarapid metabolizers and codeine
16. CYP2C9
17. Functional effect of CYP2C9 alleles
18. Warfarin
19. Vitamin K cycle
20. CYP2C9 genotypes and warfarin
21. Warfarin dose requirement
22. Vitamin K epoxide reductase
23. VKORC1 polymorphisms (1)
24. VKORC1 polymorphisms (2)
25. CYP2C9/VKORC1 genotype warfarin dose
26. Warfarin and pharmacogenetics
27. Association study on warfarin dose requirement
28. Methyltransferases
29. Thiopurine S-methyltransferase (TPMT)
30. TPMT polymorphism (1)
31. TPMT polymorphism (2)
32. Idiosyncratic adverse drug reactions
33. Simvastatin myopathy
34. Flucloxacillin-induced liver injury
35. Summary
36. References

Topics Covered

• Definition and history
• CYP2D6 polymorphism
• Pharmacogenetics of warfarin
• Thiopurine methyltransferase
• Genetics susceptibility to adverse drug reactions

Links

Series:

• Introduction to Human Genetics

Categories:

• Genetics & Epigenetics
• Pharmaceutical Sciences

Talk Citation

Publication History

• Published on December 28, 2009

Financial Disclosures

• Professor Ann Daly has no commercial/financial relationships to disclose.