• Basic Concepts
• 19 min
  1. Molecular structure of the human genome

  • Prof. Jonathan Wolfe
• 31 min
  2. Introduction to mutation and disease

  • Prof. Jonathan Wolfe
• 26 min
  3. Introduction to genetic diseases

  • Prof. Jonathan Wolfe
• 26 min
  4. Historical introduction to human diversity I

  • Prof. Dallas Swallow
• 28 min
  5. Historical introduction to human diversity II

  • Prof. Dallas Swallow
• 23 min
  6. Introduction to cytogenetics 1

  • Dr. Sioban SenGupta
• 15 min
  7. Introduction to cytogenetics 2

  • Dr. Sioban SenGupta
• 16 min
  8. Introduction to cytogenetics 3

  • Dr. Sioban SenGupta
• 42 min
  9. The Y-chromosome

  • Prof. Mark Jobling
• 42 min
  10. Mitochondrial DNA, molecular genetics and human mitochondrial diseases

  • Prof. Immo Scheffler
• 66 min
  11. Mechanisms of DNA repair by recombination

  • Prof. James Haber
• 26 min
  12. Techniques utilized in molecular genetics

  • Dr. Cecil Lewis
• 36 min
  13. Genome mapping

  • Dr. Simon Gregory
• 35 min
  14. Copy number variation

  • Dr. Ömer Gökçümen
• Genetics and Disease
• 45 min
  15. Genetic association studies

  • Prof. David Balding
• 42 min
  16. Quantitative genetics and multifactorial inheritance

  • Dr. Lara Bauman
• Human Evolutionary Genetics
• 34 min
  17. Population genetics

  • Dr. Murray P. Cox
• 59 min
  18. Inference on human history through DNA

  • Prof. Guido Barbujani
• 37 min
  19. Human adaptation

  • Prof. Rasmus Nielsen
• Specialized Topics
• 44 min
  20. Accessing and using ENCODE data

  • Prof. Peggy Farnham
• 44 min
  21. Pharmacogenetics

  • Prof. Ann Daly
• 33 min
  22. Genetics in forensics

  • Dr. Angel Carracedo
• 29 min
  23. The development and evolution of human gene therapy

  • Prof. Theodore Friedmann
• 33 min
  24. Next generation sequencing technologies

  • Dr. Krishna Veeramah

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Genetic association studies (1)
3. Genetic association studies (2)
4. Linkage vs. association (1)
5. Linkage vs. association (2)
6. Common variants for common diseases?
7. Genealogy at causal locus (haploid)
8. What if the causal locus isn't genotyped?
9. LD from shared founder haplotype
10. Strength of LD marker
11. Genetic heterogeneity
12. Genotypes at SNPs in strong LD
13. Quality Control (QC)
14. Hardy-Weinberg equilibrium
15. Principal component analysis (PCA)
16. Single SNP tests of association (general model)
17. Single SNP tests of association (1-df tests)
18. Armitage trend test
19. Logistic regression
20. Quantitative traits: linear regression
21. Bayesian analyses
22. Multiple testing
23. Multipoint SNP analyses
24. Haplotype-based analyses
25. Inferring phase
26. Problems with haplotype analyses
27. Haplotype space
28. Imputation
29. Confounding in genetic association studies
30. Population structure
31. P-P plot vs. GC-adjusted P-P plot
32. Family-based tests of linkage and association
33. Software
34. References

Topics Covered

• Linkage vs. association
• Common variants for common diseases
• Genealogy
• Linkage disequilibrium
• Founder haplotypes
• Genetic heterogeneity
• Hardy Weinberg equilibrium
• Principal component analysis
• Single SNP tests of association for case-control data
• Armitage trend test
• Logistic regression
• Quantitative traits
• Bayesian analyses
• Multiple testing
• Haplotype-based analyses
• Inferring phase
• Problems with haplotype analyses
• Imputation
• Genetic association studies
• Family-based tests of linkage and association
• Software

Links

Series:

• Introduction to Human Genetics

Categories:

• Genetics & Epigenetics
• Methods

Talk Citation

Publication History

• Published on December 28, 2009

Financial Disclosures

• Prof. David Balding has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.