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1. Introduction
2. Biology as a maze
3. Key points of lecture
4. Evolution of limbs
5. Lung disease as simplification
6. Lung development results in increased complexity
7. Haeckle's insight to evolution
8. Lung biologic continuum
9. Evolution as a mobius strip (1)
10. Cellular cooperativity of multicellular organisms
11. Cell cooperativity in evolution
12. Lung evolution
13. Photomicrograph of alveoli
14. Surfactant phylogeny
15. Reptile lung phenotypes
16. Plasticity of alveolization
17. From simple experiments.....
18. Cellular lung homeostasis
19. Cellular cooperativity
20. Image of lipofibroblast
21. Discovery of neutral lipid trafficking
22. Paradoxes in lipid trafficking
23. Paradoxes solved (1)
24. Paradoxes solved (2)
25. Paradoxes solved (3)
26. Gaining insight to the evolution of the lung
27. Alveolar homeostasis
28. Parathyroid hormone-related protein
29. Stretch stimulates PTHrP
30. Lung evolution due to PTHrP signaling
31. Rotating wall vessel
32. Effect of zero G on PTHrP (1)
33. STS-58 "rats in space"
34. Effect of zero G on PTHrP (2)
35. PTHrP knock out characteristics
36. PTHrP knock out histology
37. How PTHrP signaling 'drives' lung evolution
38. Phylogeny, ontogeny of lung (1)
39. Phylogeny, ontogeny of lung (2)
40. Phylogenetic effect of PTHrP
41. Selection for PTHrP signaling
42. Cellular lung phylogeny
43. Surface area versus septal thickness
44. PTHrP signaling/lung evolution
45. Wnt versus PTHrP in lung evolution
46. PTHrP signaling/alveolar size
47. PTHrP causes septal thinning
48. Leptin stimulates collagen
49. Leptin stimulates collagen - DATA
50. Signaling in lung evolution
51. Evolutionary selection pressure
52. Oxygen/stretch selection pressure
53. Experimental lung evolution
54. Emergent and contingent
55. Merging the different factors
56. How genes shuffle to generate novel phenotypes
57. Lung biology and treatment
58. PTHrP and lung evolution-schema
59. Schema for lung evolution
60. Evolution as a mobius strip (2)
61. References
62. For further reading

Topics Covered

• The evolution of the vertebrate lung
• Vertebrate evolution from unicellular organisms is reflected in lung development
• Stretch-regulated pathways of lung development leading to homeostasis can fail, leading to chronic lung disease
• The cell/molecular pathways that integrate lung development and homeostasis can serve to effectively diagnose and treat chronic lung disease

Links

Series:

• Evolution and Medicine

Categories:

• Clinical Practice

Therapeutic Areas:

• Respiratory Diseases

Talk Citation

Publication History

• Published on October 1, 2007
• Updated on July 7, 2011

Financial Disclosures

• Prof. John S. Torday has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.