• Basic Concepts
• 19 min
  1. Molecular structure of the human genome

  • Prof. Jonathan Wolfe
• 31 min
  2. Introduction to mutation and disease

  • Prof. Jonathan Wolfe
• 26 min
  3. Introduction to genetic diseases

  • Prof. Jonathan Wolfe
• 26 min
  4. Historical introduction to human diversity I

  • Prof. Dallas Swallow
• 28 min
  5. Historical introduction to human diversity II

  • Prof. Dallas Swallow
• 23 min
  6. Introduction to cytogenetics 1

  • Dr. Sioban SenGupta
• 15 min
  7. Introduction to cytogenetics 2

  • Dr. Sioban SenGupta
• 16 min
  8. Introduction to cytogenetics 3

  • Dr. Sioban SenGupta
• 42 min
  9. The Y-chromosome

  • Prof. Mark Jobling
• 42 min
  10. Mitochondrial DNA, molecular genetics and human mitochondrial diseases

  • Prof. Immo Scheffler
• 66 min
  11. Mechanisms of DNA repair by recombination

  • Prof. James Haber
• 26 min
  12. Techniques utilized in molecular genetics

  • Dr. Cecil Lewis
• 36 min
  13. Genome mapping

  • Dr. Simon Gregory
• 35 min
  14. Copy number variation

  • Dr. Ömer Gökçümen
• Genetics and Disease
• 45 min
  15. Genetic association studies

  • Prof. David Balding
• 42 min
  16. Quantitative genetics and multifactorial inheritance

  • Dr. Lara Bauman
• Human Evolutionary Genetics
• 34 min
  17. Population genetics

  • Dr. Murray P. Cox
• 59 min
  18. Inference on human history through DNA

  • Prof. Guido Barbujani
• 37 min
  19. Human adaptation

  • Prof. Rasmus Nielsen
• Specialized Topics
• 44 min
  20. Accessing and using ENCODE data

  • Prof. Peggy Farnham
• 44 min
  21. Pharmacogenetics

  • Prof. Ann Daly
• 33 min
  22. Genetics in forensics

  • Dr. Angel Carracedo
• 29 min
  23. The development and evolution of human gene therapy

  • Prof. Theodore Friedmann
• 33 min
  24. Next generation sequencing technologies

  • Dr. Krishna Veeramah

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Electrophoresis: a powerful technique in genetics
3. Electrophoretic mobility
4. Mobility of two different amino-acids
5. Harry Harris (1919-1994)
6. Specific detection methods
7. Mutation in phosphoglucomutase 1 (PGM1)
8. Detecting size differences by electrophoresis
9. Subtle changes - isoelectric focussing
10. Protein polymorphism
11. DNA polymorphism and electrophoresis
12. Detection of size and conformational differences
13. Detection of different number of tandem repeats
14. Genotype and phenotype
15. Crosses in the ABO blood group system
16. Difficulties in interpreting the correct genotype
17. Epistasis
18. Multiple molecular forms or isozymes/forms
19. Many proteins are encoded by multiple genes
20. Subunits of phosphorylase kinase
21. Multimeric proteins
22. Subunits of lactate dehydrogenase
23. Electrophoresis of samples from three people
24. Distinguishing multiple genes from multiple alleles
25. Analysis of enzyme polymorphism and isozyme
26. Human genome sequence HapMap
27. Functional implications of genetic variation

Topics Covered

• Electrophoresis
• Electrophoretic mobility
• Amino acids
• Specific detection methods
• Detecting protein size differences
• Ioselectric focusing
• Protein polymorphism
• DNA polymorphism and electrophoresis
• Tandem repeats
• Genotype and phenotype
• Epistasis
• Isozymes
• Many proteins are encoded by multiple genes
• Multimeric proteins
• How do we know that a protein is encoded by multiple genes/alleles?
• HapMap
• Functional implications of genetic variation

Links

Series:

• Introduction to Human Genetics

Categories:

• Genetics & Epigenetics

Talk Citation

Publication History

• Published on December 28, 2009

Financial Disclosures

• Prof. Dallas Swallow has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.