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1. Introduction
2. Viruses are the smallest parasites
3. Viruses can only be seen with electronmicroscope
4. Human viruses
5. What is cancer?
6. Clonal evolution of a cancer
7. Genes involved in cancer
8. Causes of cancer
9. Animal viruses taught us about cancer biology
10. Human viruses associated with malignancy
11. Direct and indirect oncogenesis by viruses
12. DNA tumor viruses
13. Transforming genes of DNA tumor viruses
14. Oncogenic RNA tumor viruses (retroviruses)
15. Retrovirus life cycle
16. Cell transformation by Rous sarcoma virus (1)
17. Cell transformation by Rous sarcoma virus (2)
18. Gene structure of tumor viruses
19. Oncogenes in retroviruses or activated in cells
20. Signal transduction pathways in cancer (1)
21. Signal transduction pathways in cancer (2)
22. Oncogenic viruses as a cause of cancer
23. Multifactorial causes of cancer (1)
24. Multifactorial causes of cancer (2)
25. Multifactorial causes of cancer (3)
26. Cellular homologs in KSHV genome
27. Oncogenic viruses and cancer in AIDS
28. Treat the infection or the cancer?
29. One virus leads to two or more diseases
30. Human retroviruses
31. Adult T-cell leukemia (ATL)
32. Viral cancer vaccines
33. Vaccination against infection
34. Oncogenic viruses that don't cause human cancer
35. Cancer is a rare outcome of frequent infections
36. Cancers attributable to infection worldwide in 2002
37. A 'Richter' scale of annual global mortality
38. Conclusions

Topics Covered

• Oncogenic viruses of animals and humans have given us insights into cancer in general
• Specific genes involved in cancer such as oncogenes and tumor suppressor genes were first discovered through research on tumor viruses
• Only a subset of viruses cause cancer
• For cancers caused by viruses, the viruses are a necessary but insufficient cause of the disease
• Cancer is multifactorial and different risk factors act together
• Vaccines hold great promise to reduce the cancer burden
• The incidence is higher in immunodeficient people
• Transplant recipients and AIDS

Links

Series:

• Evolution and Medicine

Categories:

• Cancer
• Clinical Practice
• Immunology

Therapeutic Areas:

• Infectious Diseases
• Oncology

Talk Citation

Publication History

• Published on October 1, 2007
• Reviewed on August 16, 2020

Financial Disclosures

• Prof. Robin Weiss has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.