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Printable Handouts
Navigable Slide Index
- Introduction
- Human genetic variation - Science 2007
- Variations can be of any scale
- Landmarks in the study of human genetic variation
- Array CGH
- Copy number variations (CNV)
- CNVs - open questions (1)
- Mouse CNV catalog
- Mouse CNV catalog - HMM scoring method
- Mouse CNV catalog - CNV prediction
- Validation of HMM - NimbleGen CGH array
- CNV in MMU7
- CNVs - open questions (2)
- CNVs and expression
- Variance of expression levels (1)
- Correlation between CNV and expression
- Negative and positive correlation
- Hypothesis for CNV and expression correlation
- Variance of expression levels (2)
- CNV genes are less expressed than non CNV
- CNV genes are more specific than non CNV
- Brain genes are less likely to be CNV
- Proportion of expression variance and CNVs (1)
- WBS syndrome - CNV and expression
- CNVs and expression - papers
- Genes mapping 50 to 250 kb from CNVs
- The effect is seen up to 450kb from CNV region
- Variance of flanking genes - mechanisms
- The generation and use of recombinant inbreds
- Recombinant inbreds - variance of expression
- Conclusions
- Acknowledgements
Topics Covered
- Genome Structure and Expression
- Human genetic variation
- Variations can be of any scale
- Landmarks in the study of human genetic variation
- Array CGH
- Copy number variations (CNV)
- CNVs
- open questions
- Mouse CNV catalog
- Validation of HMM
- NimbleGen CGH array
- CNVs and expression
- Variance of expression levels
- Correlation between CNV and expression
- Hypothesis for CNV and expression correlation
- CNV genes are less expressed than non CNV
- CNV genes are more specific than non CNV
- Brain genes are less likely to be CNV
- Proportion of expression variance and CNVs
- WBS syndrome
- CNV and expression
- Variance of flanking genes
- mechanisms
- The generation and use of recombinant inbreds
Talk Citation
Reymond, A. (2009, November 19). Genome structure and expression [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 6, 2024, from https://doi.org/10.69645/HYQC7390.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Alexandre Reymond has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.