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- Principles in Bacterial Pathogenesis
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1. The molecular basis of bacterial pathogenicity: an overview
- Prof. B. Brett Finlay
- Gram Negative Pathogens
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2. Deciphering shigella invasion of epithelial cells
- Prof. Philippe Sansonetti
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5. Bordetella pertussis
- Prof. Alison Weiss
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6. Salmonellae: molecular basis of infection
- Prof. Samuel Miller
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7. The diversity of Escherichia coli infections
- Prof. Michael Donnenberg
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8. Bacterial activation of epithelial signaling
- Prof. Alice Prince
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9. Human pathogenic Yersinia species
- Prof. James Bliska
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11. Dental pathogens
- Prof. Ann Progulske-Fox
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12. Haemophilus
- Prof. Robert Munson
- Gram Positive Pathogens
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13. The bacterial pathogen Listeria monocytogenes: an amazing multifaceted model
- Prof. Pascale Cossart
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15. Molecular pathogenesis and prevention of Staphylococcus aureus infections
- Prof. Olaf Schneewind
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16. Streptococcus pyogenes disease and molecular pathogenesis
- Prof. P. Patrick Cleary
- Host Responses
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17. Microbial recognition and the immune response
- Dr. Dana Philpott
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18. Enteric pathogens-microbiota-host inter-kingdom chemical interactions
- Prof. Vanessa Sperandio
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19. Toll-like receptor signalling during infection and inflammation
- Prof. Luke O'Neill
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20. The human indigenous microbiota
- Prof. David Relman
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22. Role of neutrophils in acute lung injury and repair
- Prof. Gregory Downey
- Preventatives and Therapeutics
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23. Antibiotics and antibiotic resistance
- Prof. Gerry Wright
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24. Vaccines: a health insurance of the 21st century
- Prof. Rino Rappuoli
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25. Biodefense vaccines
- Prof. James Nataro
- Archived Lectures *These may not cover the latest advances in the field
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26. Vaccines in the modern world
- Prof. Gordon Dougan
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27. Bacterial infection of epithelial signaling
- Prof. Alice Prince
Printable Handouts
Navigable Slide Index
- Introduction
- Tuberculosis (TB) today
- TB and HIV epidemic in South Africa
- XDR-TB in Tugela Ferry
- Patients co-infected with TB and HIV in rural SA
- Susceptibility pattern of isolates from Tugela Ferry
- Tugela Ferry
- Hospital acquired XDR-TB (1)
- Hospital acquired XDR-TB (2)
- XDR-TB realities
- XDR-TB spread in KwaZulu-Natal 2005-2007
- TB sanatorium evolution
- The war on XDR-TB - clinical needs
- M. tuberculosis knowledge - 1985 (1)
- Why is knowledge important?
- The causes for TB - 1847
- Causes of consumption - therapy
- Edward Livingston Trudeau (1)
- Edward Livingston Trudeau (2)
- Jean Antoine Villemin
- Gerhard Armauer Hansen
- Koch's postulate
- M. tuberculosis knowledge - 1985 (2)
- Molecular Koch's postulate
- First fulfillment of molecular Koch's postulate
- Why no genetics for M. tuberculosis?
- Leprosy
- Mycobacteriophage delivery vectors (1)
- Mycobacteriophage delivery vectors (2)
- fadD knockout strains
- Genetics = new knowledge
- Bacille Calmette and Guerin (BCG)
- Why is BCG attenuated?
- Molecular Koch's postulate: application to BCG
- Reconstruction of BCG
- The loss of RD1 attenuates MTB
- Primary attenuation of BCG
- Mechanism of action of INH and ETH in M. tb
- How tuberculosis may develop drug resistance
- InhA is the target of INH and ETH
- Common target of Isoniazid and Ethionamide
- Conclusions
Topics Covered
- Tuberculosis today
- Susceptibility pattern
- Hospital acquired XDR-TB
- XDR-TB realities
- TB sanatorium evolution
- Development of knowledge of TB
- Causes of consumption: Samuel Sheldon Fitch and Edward Livingston Trudeau
- Molecular Koch's postulate
- Why no genetics for M. tuberculosis?
- Mycobacteriophage delivery vectors
- Genetics = new knowledge
- Bacille Calmette and Guerin (BCG)
- Reconstruction of BCG
- Primary attenuation of BCG
- By understanding how M. Tuberculosis evades immunity it should be possible to make better vaccines than BCG
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Jacobs, W. (2009, November 24). The war against extensively drug resistant Mycobacterium tuberculosis: intelligence acquisition [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved August 31, 2024, from https://doi.org/10.69645/ITJA2085.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. William Jacobs has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
The war against extensively drug resistant Mycobacterium tuberculosis: intelligence acquisition
Published on November 24, 2009
42 min
A selection of talks on Microbiology
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