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1. Introduction
2. Oral bacterial diversity
3. The major oral diseases
4. Caries
5. Caries is a "dieto-infectious disease"
6. Stephan curve
7. The Stephan curve over the course of a day
8. Ecological basis for the development of caries
9. Requirements for cariogenicity
10. Streptococcus mutans
11. S. mutans virulence
12. The physiology of S. mutans
13. Acquisition of S. mutans
14. Adherence and accumulation of S. mutans
15. P1 (antigen I/II)
16. The P1 protein
17. Sucrose-dependent adherence
18. S. mutans biofilm formation
19. Wild-type S. mutans biofilms
20. Biofilm warfare
21. S. mutans and exo-polysaccharide metabolism
22. S. mutans and sucrose
23. S. mutans is not the only caries pathogen
24. Short summary: caries
25. Periodontal diseases
26. Periodontitis
27. Healthy vs. diseased sites
28. Bacteria and periodontal disease
29. Pathogenic process
30. Periodontopathogens model
31. Aggregatibacter actinomycetemcomitans (Aa) (1)
32. Aggregatibacter actinomycetemcomitans (Aa) (2)
33. Aa adhesins
34. Aa fimbriae
35. Aa fimbriae - change of colony morphology
36. EmaA
37. Aa toxins
38. Lipopolysaccharide of Aa
39. Leukotoxin (LtxA) (1)
40. Leukotoxin (LtxA) (2)
41. Leukotoxin operon
42. Significance of Ltx
43. Immunosuppressive factor
44. Aa invasion of host cell (1)
45. Aa invasion of host cell (2)
46. Aa attaches to host cell microvilli
47. Aa attachment to host cell
48. Aa found in membrane projections of host cell
49. TEM of Aa in projection between cells
50. Review: Aa virulence mechanisms
51. Porphyromonas gingivalis (Pg)
52. Pathogenic mechanisms of P. gingivalis
53. P. gingivalis adhesins
54. P. gingivalis fimbriae (1)
55. P. gingivalis fimbriae (2)
56. P. gingivalis hemagglutinins
57. P. gingivalis hemagglutinin genes
58. Attachment of E. coli expressing HagA
59. Attachment of E. coli expressing HagB
60. P. gingivalis proteinases
61. Gingipains (1)
62. Gingipain activity and structure
63. Gingipain translation products
64. Domain structure of gingipains
65. Gingipains (2)
66. P. gingivalis invasion
67. P. gingivalis does not invade all cell types equally
68. P. gingivalis invasion of gingival epithelial cells
69. Pg and human cardiovascular cells interaction
70. Invasion of Pg to humane cardiovascular cells (1)
71. Invasion of Pg to humane cardiovascular cells (2)
72. Colocalization of Pg in endothelial cells
73. Pg trafficking in endothelial cells
74. Invasion of Pg to humane cardiovascular cells (3)
75. Conclusion - invasion
76. Summary: factors that contribute to Pg virulence
77. Impact of oral diseases on systemic health
78. Cardiovascular and periodontal diseases
79. Patients with CVDs have periodontal diseases
80. CVDs and periodontal disease: animal studies
81. CVDs and periodontal disease: humans (1)
82. CVDs and periodontal disease: humans (2)
83. CVDs and periodontal disease: humans (3)
84. Atherosclerosis - present thinking
85. Oral bacteria affect CVS - potential mechanisms
86. The significance of bacteremia
87. Summary: CVD and periodontal diseases
88. Overall summary
89. Thank you
90. References (1)
91. References (2)

Topics Covered

• Mechanisms of dental caries
• Virulence factors of Streptococcus mutans
• Periodontal disease
• Virulence mechanisms of Aggregatibacter actinomycetemcomitans
• Virulence mechanisms of Porphyromonas gingivalis
• Periodontal diseases and cardiovascular diseases

Links

Series:

• Molecular Basis of Bacterial Infection

Categories:

• Clinical Practice
• Microbiology

Therapeutic Areas:

• Infectious Diseases
• Oral Health

Talk Citation

Publication History

• Published on October 28, 2009

Financial Disclosures

• Prof. Ann Progulske-Fox has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.