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Biomedical Basics

Electron transport and oxidative phosphorylation

  • Created by Henry Stewart Talks
Published on December 31, 2025   4 min

A selection of talks on Biochemistry

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The following session will cover electron transport chain and oxidative phosphorylation within the context of this subject, focusing on how cells generate most of their ATP through the electron transport chain and oxidative phosphorylation within the inner mitochondrial membrane. We will examine the passage of electrons through protein complexes, the creation of a proton gradient, and how ATP synthase uses this gradient to form ATP. The essential role of oxygen as the final electron acceptor and the implications of this process for cellular metabolism and disease will also be discussed. We will explore how cells extract maximum energy from nutrients through the electron transport chain or ETC, and oxidative phosphorylation, both occurring in the inner mitochondrial membrane, the cell's powerhouse. Unlike glycolysis or the citric acid cycle, these pathways produce most cellular ATP by harnessing energy from electron transfer. This lecture will discuss electron passage, the role of the proton gradient, ATP synthases mechanism, and the significance of oxygen as the final electron acceptor. At the heart of the electron transport chain are four multi subunit protein complexes, named Complex one to Complex four, embedded in the inner mitochondrial membrane. Electrons enter primarily via NADH at Complex one or FADH two, at Complex two, both from prior metabolic pathways, like the citric acid cycle. Electrons are passed through complexes via

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Electron transport and oxidative phosphorylation

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