We noted you are experiencing viewing problems
-
Check with your IT department that JWPlatform, JWPlayer and Amazon AWS & CloudFront are not being blocked by your network. The relevant domains are *.jwplatform.com, *.jwpsrv.com, *.jwpcdn.com, jwpltx.com, jwpsrv.a.ssl.fastly.net, *.amazonaws.com and *.cloudfront.net. The relevant ports are 80 and 443.
-
Check the following talk links to see which ones work correctly:
Auto Mode
HTTP Progressive Download Send us your results from the above test links at access@hstalks.com and we will contact you with further advice on troubleshooting your viewing problems. -
No luck yet? More tips for troubleshooting viewing issues
-
Contact HST Support access@hstalks.com
-
Please review our troubleshooting guide for tips and advice on resolving your viewing problems.
-
For additional help, please don't hesitate to contact HST support access@hstalks.com
We hope you have enjoyed this limited-length demo
This is a limited length demo talk; you may
login or
review methods of
obtaining more access.
Printable Handouts
Navigable Slide Index
- Introduction
- Lecture outline
- History of the cholera disease
- Vibrio cholerae - epidemiology
- Zimbabwe cholera epidemic 2008
- V. cholerae and the cholera disease
- V. cholerae: classification
- Cholera pandemics
- Cholera - the disease
- Cholera mortality can be 80% if untreated
- Problem of IV rehydration
- International center for diarrheal disease research
- Cholera pediatric ward at the ICDDR,B
- "Cholera cot"
- Rice water cholera stool
- Highlights in the history of V. cholerae research
- Rabbit intestinal loop assay
- Cholera toxin: 10ug = 20L of diarrhea in volunteers
- Colonization of the upper intestine is intense
- TCP pili bundles required for intestinal colonization
- TCP mediates formation of microcolonies in vitro
- Adherence of V. cholerae to epithelial cells
- Cholera pathogenesis
- V. cholerae is at home in water
- Conclusions from comparative genomics
- The TCP island of V. cholerae
- Cholera toxin is encoded by a filamentous phage
- Structure of the CTX prophage
- Model for emergence of pathogenic V. cholerae
- Coordinate regulation of TCP and CT
- Construction of a V. cholerae microarray
- Profiling of V. cholerae in Bangladesh
- TCP and ToxT upregulated in vomitus samples
- Conclusions from clinical samples analysis
- "Quorum sensing" measures cell density
- Analyzing cholera epidemics
- Are there any small molecules useful as drugs?
- Screen for inhibitors of ctxA transcription
- Virstatin: effect on CT and TcpA production
- Virstatin in vitro
- Virstatin in vivo
- Virstatin - first inhibitor of microbial virulence
- A seasonal cholera epidemic in Bangladesh
- What influences the seasonality of cholera?
- Environmental phage and V. cholerae isolation
- Vibriophages prevalent in Dhaka city
- Vibriophages and V. cholerae in water samples
- Incidence of cholera and phage isolation
- Cholera incidence and phage isolation - summary
- Influence of phage on cholera epidemic seasonality
- Cholera epidemic emerged after a flood in Dhaka
- Dhaka epidemic - V. cholerae and phages
- Dhaka epidemic - presence of phages in stools
- Model for the role of phage in cholera seasonality
- Phenotypic differences between biotypes
- Conclusions
- Types of cholera vaccines
- Results of Peru 15 study in adults
- Peru 15 study in infants
- Summary of results in toddlers and infants
- Acknowledgements
Topics Covered
- Vibrio cholerae epidemiology and classification
- Vibrio cholerae and cholera
- Cholera mortality
- The history of V. cholerae research
- Cholera toxin and pathogenesis
- Comparative genomics
- The TCP Island of Vibrio cholerae
- Structure of the CTX prophage
- Vibrio cholerae microarray
- Clinical sample analysis
- Virstatin
- What influences the seasonality and epidemiology of cholera?
- Vibriophages
- Cholera incidence as a function of environmental phage isolation and concentration
- Phenotypic differences between biotypes
- Types of cholera vaccines
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Mekalanos, J. (2009, October 29). Cholera: a paradigm for understanding emergence, virulence and temporal patterns of disease [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved August 14, 2024, from https://doi.org/10.69645/CDDX2764.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. John Mekalanos has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Cholera: a paradigm for understanding emergence, virulence and temporal patterns of disease
Published on October 29, 2009
57 min
A selection of talks on Infectious Diseases
Hide