• Principles in Bacterial Pathogenesis
• 43 min
  1. The molecular basis of bacterial pathogenicity: an overview

  • Prof. B. Brett Finlay
• Gram Negative Pathogens
• 50 min
  2. Deciphering shigella invasion of epithelial cells

  • Prof. Philippe Sansonetti
• 43 min
  3. Legionella pneumophila: an intracellular pathogen of phagocytes

  • Dr. Craig Roy
• 57 min
  4. Cholera: a paradigm for understanding emergence, virulence and temporal patterns of disease

  • Prof. John Mekalanos
• 34 min
  5. Bordetella pertussis

  • Prof. Alison Weiss
• 37 min
  6. Salmonellae: molecular basis of infection

  • Prof. Samuel Miller
• 43 min
  7. The diversity of Escherichia coli infections

  • Prof. Michael Donnenberg
• 18 min
  8. Bacterial activation of epithelial signaling

  • Prof. Alice Prince
• 48 min
  9. Human pathogenic Yersinia species

  • Prof. James Bliska
• 32 min
  10. From CagA to CagA: the metamorphoses of the Helicobacter pylori's cytotoxin-associated gene A into the cancer-associated gene A

  • Dr. Antonello Covacci
• 46 min
  11. Dental pathogens

  • Prof. Ann Progulske-Fox
• 35 min
  12. Haemophilus

  • Prof. Robert Munson
• Gram Positive Pathogens
• 53 min
  13. The bacterial pathogen Listeria monocytogenes: an amazing multifaceted model

  • Prof. Pascale Cossart
• 42 min
  14. The war against extensively drug resistant Mycobacterium tuberculosis: intelligence acquisition

  • Prof. William Jacobs
• 48 min
  15. Molecular pathogenesis and prevention of Staphylococcus aureus infections

  • Prof. Olaf Schneewind
• 49 min
  16. Streptococcus pyogenes disease and molecular pathogenesis

  • Prof. P. Patrick Cleary
• Host Responses
• 29 min
  17. Microbial recognition and the immune response

  • Dr. Dana Philpott
• 40 min
  18. Enteric pathogens-microbiota-host inter-kingdom chemical interactions

  • Prof. Vanessa Sperandio
• 47 min
  19. Toll-like receptor signalling during infection and inflammation

  • Prof. Luke O'Neill
• 56 min
  20. The human indigenous microbiota

  • Prof. David Relman
• 53 min
  21. Human genetics of infectious diseases: the example of bacterial/mycobacterial infections

  • Dr. Laurent Abel
• 47 min
  22. Role of neutrophils in acute lung injury and repair

  • Prof. Gregory Downey
• Preventatives and Therapeutics
• 35 min
  23. Antibiotics and antibiotic resistance

  • Prof. Gerry Wright
• 36 min
  24. Vaccines: a health insurance of the 21st century

  • Prof. Rino Rappuoli
• 41 min
  25. Biodefense vaccines

  • Prof. James Nataro
• Archived Lectures *These may not cover the latest advances in the field
• 39 min
  26. Vaccines in the modern world

  • Prof. Gordon Dougan
• 39 min
  27. Bacterial infection of epithelial signaling

  • Prof. Alice Prince

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Shigella invasion process
3. Histopathology of shigellosis
4. Functional genomics of S. flexneri
5. The shigellosis disease process
6. Two mechanisms for bacterial penetration
7. pWR100: the virulence plasmid of S. flexneri 5a
8. The Shigella invasion pathogenicity island
9. Assembly of type III protein delivery system
10. IpaB and IpaD: sensor-adaptor at the needle tip
11. Shigella trigger mechanism for cell invasion
12. Signaling in the penetration process
13. Cortactin - second wave of signaling
14. IpaC induces Src autophosphorylation
15. Src is activated early at Shigella entry site
16. Src is necessary for actin foci formation
17. Cortactin silencing blocks the entry process
18. C351 insertion in IpaC effector C-terminal domain
19. IpaC last 72 aa induce actin-foci-like structures
20. IpaC-dependent actin nucleation
21. Shigella motility within and between the cells
22. Actin-dependent intracellular motility of Shigella
23. Shigella intracellular motility - video
24. Entry and cell-to cell spread of Shigella
25. Acknowledgements

Topics Covered

• A genetic and molecular analysis of the mechanisms used by the bacterial pathogen Shigella to invade epithelial cells
• Identification of bacterial effectors of invasion, mode of delivery, nature of cell targets
• How a bacterial pathogen like Shigella causes the rupture and inflammatory destruction of the intestinal epithelial barrier
• How it also regulates the inflammatory response
• The accent is on identification of the bacterial effectors and their cellular targets

Links

Series:

• Molecular Basis of Bacterial Infection

Categories:

• Clinical Practice
• Microbiology

Therapeutic Areas:

• Infectious Diseases

Talk Citation

Publication History

• Published on October 29, 2009

Financial Disclosures

• Prof. Philippe Sansonetti has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.