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1. Introduction
2. Talk outline
3. Known facts about NK cell development (1993)
4. IL-2 and IL-15 receptors
5. IL-15 induces human NK cell differentiation
6. Factors responsible for NK cells development
7. KL/FL ligands and NK cells development (1)
8. KL/FL ligands and NK cells development (2)
9. SCF, IL-2 and IL-15 in NK cell development
10. Human natural killer cell development
11. Which CD34 subset develops into a NK cell?
12. CD34 receptor expression
13. CD34 in peripheral blood and lymph nodes
14. NK precursor selectively enriched in lymph nodes
15. Site of NK cell development
16. NK cells in lymph nodes are CD56 bright cells
17. Putative stages of human NK cell differentiation
18. NK cell development in human lymphopoiesis
19. IL-15 and human NK cell survival
20. Adoptive transfer of NK cells
21. IL-15 is required for NK cell survival in vivo
22. IL-15 and NK cell development and survival
23. The IL-15 transgene
24. NK cell expansion in IL-15tg mice
25. IL-15tg mice clinical signs and findings
26. Acute T-NK lymphoblastic leukemia
27. NK cell maturation
28. NK cell subsets
29. The immunoregulatory role of NK cell subsets
30. Where does the INF-gamma signal come from?
31. Macrophage and NK co-culture: LPS activation (1)
32. NK cell-derived IFN-gamma
33. Macrophage and NK co-culture: LPS activation (2)
34. Bright cells are the primary source of IFN-gamma
35. IFN-gamma production in bright and dim cells
36. CD56 bright NK cells in the immune response
37. Innate immunoregulator, CD56 bright
38. Innate cytotoxic effector, CD56 dim
39. How do inhibitory NKR work? (1)
40. How does KIR work?
41. How do Inhibitory NKR work? (2)
42. The inhibitory receptors bind to specific epitopes
43. Common epitopes that bind to these receptors
44. Haplo-mismatch bone marrow transplant (BMT)
45. Haplo-mismatch BMT that results in lysis
46. Haplo-mismatch BMT that results in no lysis
47. Haplo-mismatch BMT - no lysis outcome
48. Summary of haplo-mismatch BMT
49. KIR mismatch/ no mismatch
50. Conclusions
51. Summary
52. Acknowledgments

Topics Covered

• Human NK cell development
• What factors are responsible for NK cell development?
• How does KL or FL assist IL-15 in NK cell development?
• NK progenitor, NK precursor, mature NK cell
• Only CD34dimCD45RA(+) HPC differentiate into CD56bright NK cells
• NK cells are in human lymph nodes and are CD56bright
• Putative stages of human NK cell differentiation in nodes/tonsils
• How NK cell development fits in human lymphopoiesis
• IL-15 and human NK cell survival
• Adoptive transfer of NK cells into IL-15-deficient mice
• IL-15 transgene
• Lymphoblastic leukemia
• Human NK cell subsets
• Do NK cell subsets have unique immunoregulatory roles?
• LPS activation
• NK cell-derived IFN-γ in the innate immune response
• Innate immunoregulator, CD56bright
• Innate cytotoxic effector, CD56dim
• How do inhibitory NKR work?
• How does KIR work?
• Haplo-mismatch BMT

Links

Series:

• Natural Killer Cell Biology

Categories:

• Clinical Practice
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Caligiuri, M. (2009, September 23). Natural killer cells: development, diversity and applications to human disease [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/OXWK2452.
Export Citation (RIS)

Publication History

• Published on September 23, 2009

Financial Disclosures

• Prof. Mike Caligiuri has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.