Topics Covered
- NK cell "education"
- NK cells in normal animals attack cells that lack some or all self MHC class I molecules
- NK cells that lack inhibitory receptors for self MHC class I are rendered hyporesponsive and self tolerant
- Hyporesponsiveness of NK cells is induced by target cells lacking MHC I, as in a mixed chimera
- Responsiveness of NK cells varies depending on how many MHC I-specific receptors they express
- NK cell education ensures that NK cells are optimally responsive yet not autoreactive
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Raulet, D. (2009, September 23). Disarming of autoreactive NK cells [Video file]. In
The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved August 19, 2022, from
https://hstalks.com/bs/1451/.
Publication History
-
Published on September 23, 2009
Financial Disclosures
- Prof. David Raulet has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.