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Biomedical Basics

Glycolysis pathway

  • Created by Henry Stewart Talks
Published on November 30, 2025   4 min

A selection of talks on Cardiovascular & Metabolic

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In this talk, the focus is Glycolysis Pathway, supported by coverage of the key steps and regulation of the glycolysis pathway, highlighting how glucose is broken down into pyruvate through ten enzyme-catalyzed reactions. We will discuss the pathway’s two phases—investment and payoff—emphasizing ATP and NADH production. The lecture will also explain how glycolysis is tightly regulated by key enzymes to match cellular energy needs. Finally, we’ll examine the diverse fates of pyruvate and the importance of glycolytic intermediates in metabolism.. We will explore the glycolysis pathway, a central and ancient metabolic process in biology. Glycolysis breaks down glucose, a six-carbon sugar, into two molecules of pyruvate, occurring in the cytosol of almost all living cells, regardless of oxygen. Glycolysis not only underpins energy production, but also supplies intermediates for various biosynthetic pathways. The process transforms glucose step by step through the action of enzymes, releasing usable energy. Let’s outline the flow of carbon through glycolysis. This pathway has ten enzyme-catalyzed reactions, divided into investment and payoff phases. In the investment phase, glucose is phosphorylated and rearranged, consuming two ATP. Hexokinase catalyzes the first step: glucose to glucose-six-phosphate. PFK-one converts fructose-six-phosphate to fructose-one,

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