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1. Introduction
2. Outline
3. Fever is part of the acute phase response (APR)
4. Fever
5. Normothermia, hypothermia and hyperthermia
6. Body temperature raise by mammals during fever
7. Temperature regulation is a reflex
8. Finding the role of fever in disease (1)
9. Finding the role of fever in disease (2)
10. Could an ectotherm be used as an animal model?
11. Why would an ectotherm be a good animal model?
12. Desert iguana: the selected animal model
13. Experimental setup used to study fever in lizards
14. Fever in the lizard Dipsosaurus dorsalis
15. Other characteristics of fever in lizards
16. How prevalent is fever in the animal kingdom?
17. Example - crickets
18. Example - grasshoppers
19. Examples of fever in ectotherms
20. Fever and survival in infected lizards
21. Effect of sodium salicylate on infected lizards
22. Evidence that fever enhances host defenses
23. Biological effects of temperature
24. Effects of febrile temperature on host defense
25. Fever is adaptive - another evidence
26. Fever and Darwinian medicine
27. Fever therapy - sweat lodge
28. Fever therapy - sauna
29. Fever therapy - thermal vapor bath
30. Why doesn't antipyretic drug therapy kill?
31. Other acute phase responses
32. Darwinian medicine - conclusion

Topics Covered

• Evolutionary history of fever
• Role of fever in disease
• Role of related host defenses in disease
• Concept of Darwinian Medicine

Links

Series:

• Evolution and Medicine

Categories:

• Clinical Practice
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on October 1, 2007
• Reviewed on August 16, 2020

Financial Disclosures

• Prof. Matthew Kluger has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.