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1. Introduction
2. Energy metabolism in the hypothalamus
3. The arcuate nucleus
4. POMC and energy regulation
5. Congenics mapping and adiposity phenotype
6. Obesity traits for the B6.C-D7Mit353 strain
7. Prcp mRNA expression in the brain
8. PRCP
9. Alpha-MSH peptide sequence
10. Alpha-MSH is a substrate of PRCP
11. LC MS analysis of alpha-MSH-PRCP reaction
12. Effect of alpha-MSH on food intake
13. Effect of alpha-MSH1-13 on MC4R
14. Generation of PRCP gene-trap mice
15. PRCP expression in Prcp null mice
16. PRCP expressing cells in the hypothalamus
17. Identification of PRCP expressing neurons
18. PRCP gene-trap mice: phenotype
19. Alpha-MSH levels in PRCP gene-trap mice
20. Alpha MSH and MTII effect on food intake
21. Effect of PRCP inhibitors on food intake
22. ZPP effect in obese mice
23. ZPP acts on melanocortin receptors
24. BPP effect on food intake
25. BPP effect in obese mice
26. RNAi mediated knockdown of PRCP in the DMH
27. PRCP mRNA is increased in the hypothalamus
28. Summary
29. Acknowledgements

Topics Covered

• The hypothalamus
• POMC
• Congenics mapping
• PRCP
• alpha-MSH peptide sequence
• Effect of alpha-MSH on food intake
• Generation of PRCP gene-trap mice
• Prcpgt/gt mice are leaner and resistant to diet-induced obesity
• Effect of PRCP inhibitors on food intake
• PRCP mRNA is increased in the hypothalamus of Dio mice

Links

Categories:

• Metabolism & Nutrition
• Neuroscience

Therapeutic Areas:

• Cardiovascular & Metabolic
• Neurology

Talk Citation

Diano, S. (2010, March 31). Hypothalamic prolylcarboxypeptidase (PRCP) in the regulation of melanocortin system [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/ZQWP1030.
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Publication History

• Published on March 31, 2010

Financial Disclosures

• Dr. Sabrina Diano has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.