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Printable Handouts
Navigable Slide Index
- Introduction
- Basic replication fork anatomy
- Obstacles to replication fork progression
- Topological stress ahead of replication fork
- Topoisomerases remove topological stress
- Topoisomerase II relaxes newly replicated strands
- Topoisomerase II mechanism of work
- Cellular response to template lesions in replication
- Checkpoint responses to stalled forks
- Fork stabilisation
- Coping with DNA lesions in replication template
- DNA repair by excision mechanisms
- DNA damage bypass at the fork
- Regulation of DNA damage bypass choice
- DNA damage bypass: translesion synthesis
- Translesion synthesis polymerases
- DNA damage bypass: template switching models
- Fork regression mechanisms
- Template switching mechanisms
- Recombination structures in template switching
- Co-directional replication and transcription
- Head-on collision of replication and transcription
- Replication and transcription of ribosomal genes
- Replication fork on rDNA
- Protein roadblocks and Rrm3 helicase
- Recombination and replication
- Summary and conclusions
Topics Covered
- Replication fork anatomy
- Obstacles to replication fork progression
- Topological stress
- Fork stabilisation
- DNA repair
- DNA damage bypass
- Translesion synthesis
- Template switching models
- Fork regression mechanisms
- Co-directional replication and transcription
Talk Citation
Aragón, L. (2009, June 29). Regulation of replication fork progression and stability [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved January 26, 2021, from https://hstalks.com/bs/1335/.Publication History
Financial Disclosures
- Dr. Luis Aragón has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Regulation of replication fork progression and stability
Published on June 29, 2009
48 min