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1. Introduction
2. Basic replication fork anatomy
3. Obstacles to replication fork progression
4. Topological stress ahead of replication fork
5. Topoisomerases remove topological stress
6. Topoisomerase II relaxes newly replicated strands
7. Topoisomerase II mechanism of work
8. Cellular response to template lesions in replication
9. Checkpoint responses to stalled forks
10. Fork stabilisation
11. Coping with DNA lesions in replication template
12. DNA repair by excision mechanisms
13. DNA damage bypass at the fork
14. Regulation of DNA damage bypass choice
15. DNA damage bypass: translesion synthesis
16. Translesion synthesis polymerases
17. DNA damage bypass: template switching models
18. Fork regression mechanisms
19. Template switching mechanisms
20. Recombination structures in template switching
21. Co-directional replication and transcription
22. Head-on collision of replication and transcription
23. Replication and transcription of ribosomal genes
24. Replication fork on rDNA
25. Protein roadblocks and Rrm3 helicase
26. Recombination and replication
27. Summary and conclusions

Topics Covered

• Replication fork anatomy
• Obstacles to replication fork progression
• Topological stress
• Fork stabilisation
• DNA repair
• DNA damage bypass
• Translesion synthesis
• Template switching models
• Fork regression mechanisms
• Co-directional replication and transcription

Links

Series:

• The Cell Division Cycle

Categories:

• Cell Biology

Therapeutic Areas:

• Oncology

Talk Citation

Publication History

• Published on June 29, 2009

Financial Disclosures

• Dr. Luis Aragón has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.