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- Models of Investigation
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41 min
1. Antifungal innate immunity in C. elegans- Dr. Jonathan Ewbank
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44 min
2. The anti-microbial defense of Drosophila: a paradigm for innate immunity- Prof. Jules Hoffmann
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38 min
3. Phagocytosis in the fruit fly, Drosophila melanogaster- Dr. Lynda Stuart
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62 min
4. Innate immune sensing and response- Prof. Bruce Beutler
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61 min
5. Macrophages and systems biology- Prof. David Hume
- Cell Types and Recruitment
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71 min
6. Leukocyte recruitment in vivo- Prof. Paul Kubes
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51 min
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42 min
8. Eosinophils- Prof. Tim Williams
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63 min
9. Dendritic cells: linking innate to different forms of adaptive immunity- Prof. Ralph Steinman
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25 min
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61 min
11. Innate-like lymphocytes 1- Prof. Adrian Hayday
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41 min
12. Innate-like lymphocytes 2- Prof. Adrian Hayday
- Recognition and Signaling
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50 min
13. Colony stimulating factor-1 regulation of macrophages in development and disease- Prof. E. Richard Stanley
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42 min
14. Fc receptors: linking innate and acquired immunity- Prof. Ken G C Smith
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39 min
15. Phagocytosis- Prof. Joel Swanson
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44 min
16. Clearance of apoptotic cells and the control of inflammation- Prof. Sir John Savill
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38 min
17. Signaling by innate immune receptors- Prof. Michael Karin
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41 min
18. Nuclear receptors at the crossroads of inflammation and atherosclerosis- Prof. Christopher Glass
- Modulation of Effector Responses
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22 min
19. Humoral innate immunity and the acute phase response 1- Prof. Alberto Mantovani
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42 min
20. Humoral innate immunity and the acute phase response 2- Prof. Alberto Mantovani
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54 min
21. Cytokines regulating the innate response- Prof. Anne O’Garra
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39 min
22. Arginase and nitric oxide- Dr. Peter Murray
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38 min
23. Novel lipid mediators in resolution of inflammation- Prof. Charles Serhan
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69 min
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42 min
25. Cationic peptides in innate immunity- Dr. Dawn Bowdish
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27 min
26. Iron metabolism and innate immunity- Prof. Tomas Ganz
- Pathogen-Host Interactions
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46 min
27. Innate recognition of viruses- Prof. Caetano Reis e Sousa
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50 min
28. Type I interferons in innate immunity to viral infections- Prof. Christine Biron
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56 min
29. HIV-1 and immunopathogenesis: innate immunity- Prof. Luis Montaner
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53 min
30. Understanding and combating tuberculosis- Prof. David Russell
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34 min
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51 min
32. Innate immunity and malaria- Prof. Douglas Golenbock
- Health and Disease
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39 min
33. Innate immunity in children- Prof. David Speert
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59 min
34. From bench to bedside: evolution of anti-TNFalpha therapy in rheumatoid arthritis- Prof. Sir Ravinder Maini
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33 min
35. NOD-like receptors in innate immunity and inflammatory disease- Prof. Gabriel Nunez
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38 min
36. Paneth cells in innate immunity and inflammatory bowel disease- Prof. Satish Keshav
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36 min
37. Innate immunity in the brain in health and disease- Prof. V. Hugh Perry
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54 min
38. The fate of monocytes in atherosclerosis- Prof. Gwendolyn Randolph
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49 min
39. Macrophages, a cellular toolbox used by tumors to promote progression and metastasis- Prof. Jeffrey Pollard
- Archived Lectures *These may not cover the latest advances in the field
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73 min
40. Monocyte/macrophages in innate immunity- Prof. Emeritus Siamon Gordon
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32 min
41. Innate immunity in C. elegans- Dr. Jonathan Ewbank
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51 min
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39 min
43. NLR genes: infection, inflammation and vaccines- Prof. Jenny Ting
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63 min
44. Manipulation of innate immune response: lessons from shigella- Prof. Philippe Sansonetti
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35 min
45. Innate immunity of the lung and adaptation to air breathing at birth- Prof. Jeffrey Whitsett
Printable Handouts
Navigable Slide Index
- Introduction
- Outline
- What is innate immunity? (1)
- Critical role of innate immunity in children (1)
- Critical role of innate immunity in children (2)
- Elements of the immune system (1)
- Elements of the immune system (2)
- Defect in nonspecific immunity
- Defect in adaptive immunity
- Elements of the innate immune system
- The cellular and humoral arms
- Cellular elements for innate defense
- Functions of the phagocytic system
- Humoral arm of the innate immune system
- Complement in innate defense
- Complement cascade
- Opsonization
- Complement-mediated lysis
- Inflammation: a fine balance
- The canonical NFkappa-B pathway
- Innate immunity -- sensing and signaling
- NF-kappa-B structure
- Defects that cause immunodeficiency in children
- Inflammatory dysfunction
- Child with IRAK-4 deficiency
- IRAK-4 deficient macrophage response to LPS
- Phenotype of IRAK-4 deficiency
- STAT-1 deficiency
- UNC-93B deficiency
- IL-12 / interferon-gamma axis defect
- Phagocytes in innate defense
- Phagocytosis
- Leukocyte adhesion deficiency
- Lesions in LAD patient
- LAD patient at one year of age
- Chronic granulomatous disease
- Molecular defects in CGD
- Manifestations of CGD
- Patient with mild CGD
- Patient with severe CGD
- Genetic polymorphisms and the innate immunity
- Therapeutic approaches
- Strategies to enhance/arm innate immune system
- Conclusions
Topics Covered
- Host defense in children is composed of non-specific, innate and adaptive limbs
- Innate immunity is critical in defense against infection in children
- Innate immunity is composed of cellular and humoral elements
- Defects in innate immunity provide powerful insights into the importance of this limb of the host defense system in defense against infection
- New therapeutic strategies are being developed based upon novel observations of innate immunodeficiencies in children
Talk Citation
Speert, D. (2009, May 31). Innate immunity in children [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 21, 2024, from https://doi.org/10.69645/SLQL3285.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. David Speert has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
