• Models of Investigation
• 41 min
  1. Antifungal innate immunity in C. elegans

  • Dr. Jonathan Ewbank
• 44 min
  2. The anti-microbial defense of Drosophila: a paradigm for innate immunity

  • Prof. Jules Hoffmann
• 38 min
  3. Phagocytosis in the fruit fly, Drosophila melanogaster

  • Dr. Lynda Stuart
• 62 min
  4. Innate immune sensing and response

  • Prof. Bruce Beutler
• 61 min
  5. Macrophages and systems biology

  • Prof. David Hume
• Cell Types and Recruitment
• 71 min
  6. Leukocyte recruitment in vivo

  • Prof. Paul Kubes
• 51 min
  7. Chemokines and inflammation: a critical assessment of therapeutic targets

  • Dr. David Greaves
• 42 min
  8. Eosinophils

  • Prof. Tim Williams
• 63 min
  9. Dendritic cells: linking innate to different forms of adaptive immunity

  • Prof. Ralph Steinman
• 25 min
  10. Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmunity

  • Prof. Yong-Jun Liu
• 61 min
  11. Innate-like lymphocytes 1

  • Prof. Adrian Hayday
• 41 min
  12. Innate-like lymphocytes 2

  • Prof. Adrian Hayday
• Recognition and Signaling
• 50 min
  13. Colony stimulating factor-1 regulation of macrophages in development and disease

  • Prof. E. Richard Stanley
• 42 min
  14. Fc receptors: linking innate and acquired immunity

  • Prof. Ken G C Smith
• 39 min
  15. Phagocytosis

  • Prof. Joel Swanson
• 44 min
  16. Clearance of apoptotic cells and the control of inflammation

  • Prof. Sir John Savill
• 38 min
  17. Signaling by innate immune receptors

  • Prof. Michael Karin
• 41 min
  18. Nuclear receptors at the crossroads of inflammation and atherosclerosis

  • Prof. Christopher Glass
• Modulation of Effector Responses
• 22 min
  19. Humoral innate immunity and the acute phase response 1

  • Prof. Alberto Mantovani
• 42 min
  20. Humoral innate immunity and the acute phase response 2

  • Prof. Alberto Mantovani
• 54 min
  21. Cytokines regulating the innate response

  • Prof. Anne O’Garra
• 39 min
  22. Arginase and nitric oxide

  • Dr. Peter Murray
• 38 min
  23. Novel lipid mediators in resolution of inflammation

  • Prof. Charles Serhan
• 69 min
  24. Resolvins activate inflammation-resolution programs: a systems approach to resolution

  • Prof. Charles Serhan
• 42 min
  25. Cationic peptides in innate immunity

  • Dr. Dawn Bowdish
• 27 min
  26. Iron metabolism and innate immunity

  • Prof. Tomas Ganz
• Pathogen-Host Interactions
• 46 min
  27. Innate recognition of viruses

  • Prof. Caetano Reis e Sousa
• 50 min
  28. Type I interferons in innate immunity to viral infections

  • Prof. Christine Biron
• 56 min
  29. HIV-1 and immunopathogenesis: innate immunity

  • Prof. Luis Montaner
• 53 min
  30. Understanding and combating tuberculosis

  • Prof. David Russell
• 34 min
  31. The taste of a fungus: recognition of Candida by the innate immune system

  • Prof. Neil Gow
• 51 min
  32. Innate immunity and malaria

  • Prof. Douglas Golenbock
• Health and Disease
• 39 min
  33. Innate immunity in children

  • Prof. David Speert
• 59 min
  34. From bench to bedside: evolution of anti-TNFalpha therapy in rheumatoid arthritis

  • Prof. Sir Ravinder Maini
• 33 min
  35. NOD-like receptors in innate immunity and inflammatory disease

  • Prof. Gabriel Nunez
• 38 min
  36. Paneth cells in innate immunity and inflammatory bowel disease

  • Prof. Satish Keshav
• 36 min
  37. Innate immunity in the brain in health and disease

  • Prof. V. Hugh Perry
• 54 min
  38. The fate of monocytes in atherosclerosis

  • Prof. Gwendolyn Randolph
• 49 min
  39. Macrophages, a cellular toolbox used by tumors to promote progression and metastasis

  • Prof. Jeffrey Pollard
• Archived Lectures *These may not cover the latest advances in the field
• 73 min
  40. Monocyte/macrophages in innate immunity

  • Prof. Emeritus Siamon Gordon
• 32 min
  41. Innate immunity in C. elegans

  • Dr. Jonathan Ewbank
• 51 min
  42. Antigen processing and presentation: modulation by innate immune signals

  • Prof. Colin Watts
• 39 min
  43. NLR genes: infection, inflammation and vaccines

  • Prof. Jenny Ting
• 63 min
  44. Manipulation of innate immune response: lessons from shigella

  • Prof. Philippe Sansonetti
• 35 min
  45. Innate immunity of the lung and adaptation to air breathing at birth

  • Prof. Jeffrey Whitsett

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Adaptive immune response
3. Th1 and Th2 cells in immune regulation
4. Testing Th1 and Th2 differentiation
5. IL-4 and IL-12 for the development of T cells
6. Th1/ 2 existence in humans originally doubted
7. Exemplifying the controversy
8. Cytokines regulate the development of Th1/2 cells
9. Th1/2 paths of differentiation and commitment
10. Th2 pathway
11. IL-12 and Th1 are required for resistance to MTb
12. Role of TNF in controlling MTb infection in humans
13. Regulation of IFN-gamma production by Th1 cells
14. The IL-12 family
15. IL-12 versus IL-23 in antimicrobial responses
16. IL-12 and IFN-gamma in infection and pathology
17. IL-23 is the critical cytokine for EAE pathology (1)
18. Immunized cells expressing different cytokines
19. IL-23 is the critical cytokine for EAE pathology (2)
20. Th1 and ThIL-17
21. Confirmation of IL-23 and IL-12 roles in immunity
22. TGF-beta
23. Summary of CD4 T cells differentiation pathways
24. TGF-beta requirement for TH-17 development (1)
25. TGF-beta requirement for TH-17 development (2)
26. The different T cell subsets
27. Importance of regulating inflammatory responses
28. IL-10 production and function
29. Foxp3 regulatory T cells
30. The discovery of IL-10
31. B cells produce IL-10 and can stimulate Th1 cells
32. IL-10: an anti-inflammatory cytokine
33. IL-10 limits the immune response
34. Role of IL-10 in immune responses
35. Differentiation of IL-10 producing T cells
36. In vivo peptide antigen tolerization protocol
37. Results from the repeated administration of antigen
38. Tolerance induction by soluble antigen
39. TCR- transgenic transfer model for tolerance
40. Effect of IL-10 neutralization and LPS presence
41. IL-10 knockout versus Foxp3 knockouts
42. IL-10 production - summary
43. Complexity of the immune response
44. Innate immune response
45. TLR dependent and independent induction of IL-10
46. Cytokines limit immunopathology
47. IL-10 suppresses the immune response to MTb
48. Summary
49. Outstanding questions
50. Future thinking

Topics Covered

• Th1 and Th2 cells in immune regulation
• Th1 and Th2 differentiation
• Intracellular pathogens
• Cytokines regulate the development of Th1 and Th2
• IL-12 and Th1 responses are required for resistance to mycobacterial infections
• MTb infections in humans
• The IL-12 family
• IL-23
• TGF-beta
• Inflammation is required to eradicate pathogens but can lead to host damage
• IL-10 production and implications for function of the immune response
• Cytokines limit immunopathology: a penalty is chronic infectious disease

Links

Series:

• Innate Immunity

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on May 31, 2009

Financial Disclosures

• Prof. Anne O’Garra has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.