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1. Introduction
2. What is 'evolutionary genetic epidemiology'?
3. Goals of evolutionary genetic epidemiology
4. Evolutionary-mediated human disease phenotypes
5. Genetic dissection of complex traits
6. How are genetic association studies pursued? (1)
7. How are genetic association studies pursued? (2)
8. Whole genome association (WGA) studies
9. Recent large-scale WGA initiatives in the US
10. Combining evolution with association studies
11. Polymorphism: the 'wheat' and the 'chaffe'
12. Population stratification and false positive results
13. Genetic heterogeneity and false negative results
14. Evolutionary conservation and putative functionality
15. Genetic variation in CHGA gene
16. DNA sequence vs. structural conservation
17. Human genetic background heterogeneity
18. Genotypic/phenotypic differentiation maintenance
19. Shifting balance of evolution theory
20. Classical 'supervised' studies
21. Contemporary 'unsupervised' studies
22. Use of tree diagrams to represent genetic diversity
23. Diseases differ in frequency across populations
24. Lactase phenotype and population differentiation
25. ASPM gene and population differentiation
26. Overcoming stratification/heterogeneity problem
27. Sorting out genetic backgrounds of individuals
28. Race, genetic background, and drug prescriptions
29. Race and analysis of genetic variation
30. Ancestry informative markers (AIMs)
31. Example admixture studies using AIMs
32. Global map of skin pigmentation levels
33. Melanin content and individual ancestry
34. The "evolution" of human communities
35. Genetic demography variation in local community
36. Community metagenomic analysis
37. Conclusions
38. The Schork laboratory: 2006-2008

Topics Covered

• What is 'evolutionary genetics'?
• Evolution, genetic variation and association analyses
• Withinspecies diversity and population genetics
• Human genetic diversity and phenotypic variation
• Human community 'metagenomics'

Links

Series:

• Evolution and Medicine

Categories:

• Genetics & Epigenetics

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on February 25, 2021

Financial Disclosures

• Prof. Nicholas Schork has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.